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Literature summary for 7.2.2.13 extracted from

  • Pocas, E.S.; Lopes, D.V.; da Silva, A.J.; Pimenta, P.H.; Leitao, F.B.; Netto, C.D.; Buarque, C.D.; Brito, F.V.; Costa, P.R.; Noel, F.
    Structure-activity relationship of wedelolactone analogues: structural requirements for inhibition of Na+, K+ -ATPase and binding to the central benzodiazepine receptor (2006), Bioorg. Med. Chem., 14, 7962-7966.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
1,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one i.e. wedelolactone, inhibitor of kidney Na+K+-ATPase and ligand for the central benzodiazepine receptor Rattus norvegicus
2,3-dihydroxy-6H-[1,3]dioxolo[5,6][1]benzofuro[3,2-c]chromen-6-one inhibitor of kidney Na+K+-ATPase and ligand for the central benzodiazepine receptor Rattus norvegicus
2,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one inhibitor of kidney Na+K+-ATPase and ligand for the central benzodiazepine receptor Rattus norvegicus
2,9-dihydroxy-3,8-dimethoxy-6H-[1]benzofuro[3,2-c]chromen-6-one inhibitor of kidney Na+K+-ATPase and ligand for the central benzodiazepine receptor Rattus norvegicus
3,8,9-trihydroxy-2-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one inhibitor of kidney Na+K+-ATPase and ligand for the central benzodiazepine receptor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0007
-
 37°C, pH 7.4 Rattus norvegicus 1,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one
0.0007
-
 37°C, pH 7.4 Rattus norvegicus 2,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one
0.003
-
 37°C, pH 7.4 Rattus norvegicus 2,3-dihydroxy-6H-[1,3]dioxolo[5,6][1]benzofuro[3,2-c]chromen-6-one
0.003
-
 37°C, pH 7.4 Rattus norvegicus 3,8,9-trihydroxy-2-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one
0.006
-
 37°C, pH 7.4 Rattus norvegicus 2,9-dihydroxy-3,8-dimethoxy-6H-[1]benzofuro[3,2-c]chromen-6-one