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Literature summary for 7.2.2.13 extracted from

  • Peluffo, R.D.; Hara, Y.; Berlin, J.R.
    Quaternary organic amines inhibit Na,K pump current in a voltage-dependent manner: direct evidence of an extracellular access channel in the Na,K-ATPase (2004), J. Gen. Physiol., 123, 249-263.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.13

Inhibitors

Inhibitors Comment Organism Structure
benzyltriethylammonium chloride inhibition of pump current is dependent on membrane potential Rattus norvegicus
Ouabain
-
 Rattus norvegicus
tetraethylammonium chloride inhibition of pump current is independent on membrane potential Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphate + Na+/out Rattus norvegicus each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP ATP + H2O + Na+/in
-
 ?
ATP + H2O + K+/in Rattus norvegicus
-
 ADP + phosphate + K+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
myocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphate + Na+/out
-
 Rattus norvegicus ATP + H2O + Na+/in
-
 ?
ADP + phosphate + Na+/out each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP Rattus norvegicus ATP + H2O + Na+/in
-
 ?
ATP + H2O + K+/in
-
 Rattus norvegicus ADP + phosphate + K+/out
-
 ?

Synonyms

Synonyms Comment Organism
Na,K pump
-
 Rattus norvegicus
Na,K-ATPase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 myocytes in the experimental chamber for measurement of Na+-K+ pump current Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 myocytes in the experimental chamber for measurement of Na+-K+ pump current Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4
-
 benzyltriethylammonium chloride half maximum inhibition of Na,K-pump current Rattus norvegicus
26.6
-
 tetraethylammonium chloride half maximum inhibition of Na,K-pump current Rattus norvegicus