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Literature summary for 7.2.2.12 extracted from

  • Lekeux, G.; Crowet, J.M.; Nouet, C.; Joris, M.; Jadoul, A.; Bosman, B.; Carnol, M.; Motte, P.; Lins, L.; Galleni, M.; Hanikenne, M.
    Homology modeling and in vivo functional characterization of the zinc permeation pathway in a heavy metal P-type ATPase (2019), J. Exp. Bot., 70, 329-341 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.12

Protein Variants

Protein Variants Comment Organism
D149A the mutant shows about 135% of wild type Zn2+-transporting activity Arabidopsis thaliana
D181A the mutant shows wild type Zn2+-transporting activity Arabidopsis thaliana
D313A the mutant shows about 130% of wild type Zn2+-transporting activity Arabidopsis thaliana
D688A the mutant shows about 20% of wild type Zn2+-transporting activity Arabidopsis thaliana
E169A the mutant shows about 25% of wild type Zn2+-transporting activity Arabidopsis thaliana
F177A the mutant shows about 95% of wild type Zn2+-transporting activity Arabidopsis thaliana
F177L the mutant shows about 40% of wild type Zn2+-transporting activity and reduced Cd2+-transporting activity (about 20%) compared to the wild type enzyme Arabidopsis thaliana
G360A the mutant shows about 75% of wild type Zn2+-transporting activity Arabidopsis thaliana
K138A the mutant shows about 110% of wild type Zn2+-transporting activity Arabidopsis thaliana
K667A the mutant shows about 30% of wild type Zn2+-transporting activity Arabidopsis thaliana
N151A the mutant shows about 70% of wild type Zn2+-transporting activity Arabidopsis thaliana
P366L the mutant shows about 15% of wild type Zn2+-transporting activity Arabidopsis thaliana
V154A the mutant shows about 60% of wild type Zn2+-transporting activity Arabidopsis thaliana
V154S the mutant shows about 60% of wild type Zn2+-transporting activity Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cd2+[side 1] Arabidopsis thaliana
-
 ADP + phosphate + Cd2+[side 2]
-
 ?
ATP + H2O + Zn2+[side 1] Arabidopsis thaliana
-
 ADP + phosphate + Zn2+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cd2+[side 1]
-
 Arabidopsis thaliana ADP + phosphate + Cd2+[side 2]
-
 ?
ATP + H2O + Zn2+[side 1]
-
 Arabidopsis thaliana ADP + phosphate + Zn2+[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
HMA4
-
 Arabidopsis thaliana
P1B ATPase heavy metal ATPase 4
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function the enzyme is responsible for zinc and cadmium translocation from roots to shoots in Arabidopsis thaliana Arabidopsis thaliana