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Literature summary for 7.1.2.1 extracted from

  • Orie, N.N.; Warren, A.R.; Basaric, J.; Lau-Cam, C.; Pi?tka-Ottlik, M.; M?ochowski, J.; Billack, B.
    In vitro assessment of the growth and plasma membrane H+-ATPase inhibitory activity of ebselen and structurally related selenium- and sulfur-containing compounds in Candida albicans (2017), J. Biochem. Mol. Toxicol., 31, e21892 .
    View publication on PubMed
Search for more literature for 7.1.2.1

Inhibitors

Inhibitors Comment Organism Structure
2-methylbenzisoselenazol-3(2H)-one
-
 Candida albicans
2-n-propylbenzisoselenazol-3(2H)-one
-
 Candida albicans
2-phenyl-7-azabenzisoselenazol-3(2H)-one
-
 Candida albicans
2-phenylbenzisothiazol-3(2H)-one
-
 Candida albicans
benzisoselenazol-3(2H)-one
-
 Candida albicans
ebselen i.e. 2-phenylbenzisoselenazol-3(2H)-one Candida albicans
fluconazole
-
 Candida albicans
sodium orthovanadate
-
 Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+[side 1] Candida albicans
-
 ADP + phosphate + H+[side 2]
-
 ?
ATP + H2O + H+[side 1] Candida albicans S2
-
 ADP + phosphate + H+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Candida albicans
-
-
-
Candida albicans S2
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+[side 1]
-
 Candida albicans ADP + phosphate + H+[side 2]
-
 ?
ATP + H2O + H+[side 1]
-
 Candida albicans S2 ADP + phosphate + H+[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
plasma membrane H+-ATPase
-
 Candida albicans
Pma1p
-
 Candida albicans

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.01686
-
 pH and temperature not specified in the publication Candida albicans 2-phenyl-7-azabenzisoselenazol-3(2H)-one
0.01814
-
 pH and temperature not specified in the publication Candida albicans ebselen
0.01969
-
 pH and temperature not specified in the publication Candida albicans 2-phenylbenzisothiazol-3(2H)-one
0.03345
-
 pH and temperature not specified in the publication Candida albicans 2-n-propylbenzisoselenazol-3(2H)-one
0.06615
-
 pH and temperature not specified in the publication Candida albicans 2-methylbenzisoselenazol-3(2H)-one
0.1
-
 IC50 above 0.1 mM, pH and temperature not specified in the publication Candida albicans fluconazole
0.1
-
 IC50 above 0.1 mM, pH and temperature not specified in the publication Candida albicans benzisoselenazol-3(2H)-one