Application | Comment | Organism |
---|---|---|
medicine | low prenatal Cu intake by dams is the determinant of CCO activity in cardiac mitochondria of 21-d-old offspring and may lead to the assembly of a less-than-fully active holoenzyme | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | CCO activity, the content of the mitochondrial-encoded CCO subunit 1 (COX1), and the content of the nuclear-encoded subunit COX4 in cardiac mitochondria are reduced in 21-d-old offspring of Cu-deficient dams. COX1 content is normal in 21-d-old cross-fostered offspring of Cu-deficient dams, but CCO activity and COX4 are reduced | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
female Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ferrocytochrome c + O2 + H+ | - |
Rattus norvegicus | ferricytochrome c + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CCO | - |
Rattus norvegicus |
CCO subunit 1 | - |
Rattus norvegicus |
COX1 | - |
Rattus norvegicus |
COX4 | - |
Rattus norvegicus |
cytochrome c oxidase | - |
Rattus norvegicus |