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Literature summary for 7.1.1.1 extracted from

  • Ward, N.P.; Kang, Y.P.; Falzone, A.; Boyle, T.A.; DeNicola, G.M.
    Nicotinamide nucleotide transhydrogenase regulates mitochondrial metabolism in NSCLC through maintenance of Fe-S protein function (2020), J. Exp. Med., 217, e20191689 .
    View publication on PubMed
Search for more literature for 7.1.1.1

Application

Application Comment Organism
medicine NNT expression significantly enhances tumor formation and aggressiveness in mouse models of lung tumor initiation and progression Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13423
-
-
Mus musculus Q61941
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
lung
-
 Mus musculus
-
NCI-H1299 cell
-
 Homo sapiens
-
NCI-H2009 cell
-
 Homo sapiens
-
NCI-H441 cell
-
 Homo sapiens
-
non-small cell lung cancer cell
-
 Mus musculus
-
PC-9 cell
-
 Homo sapiens
-

General Information

General Information Comment Organism
physiological function NNT loss does not compromise the mitochondrial thioredoxin antioxidant system but compromises mitochondrial oxidative capacity. The activity of complex I-III is significantly reduced following NNT knockdown. NNT loss does not disrupt Fe-S cluster biosynthesis but is associated with decreases in mitochondrial Fe-S protein function and disrupts fatty acid metabolism Homo sapiens