Application | Comment | Organism |
---|---|---|
medicine | induction of pyruvate decarboxylase during chronic suppression of glutamine metabolism is a mechanism of resistance to therapies targeting glutaminolysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
guard cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
Huh-7 cell | - |
Homo sapiens | - |
LN-229 cell | - |
Homo sapiens | - |
SF-xL cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | pyruvate carboxylase (PC) is required for glutamine-independent growth of tumor cells. PC-mediated, glucose-dependent anaplerosis allows cells to achieve glutamine independence. PC is required for cell growth during glutamine deprivation | Homo sapiens |