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Literature summary for 6.3.3.2 extracted from

  • Jolivet, J.
    Human 5,10-methenyltetrahydrofolate synthetase (1997), Methods Enzymol., 281, 162-170.
    View publication on PubMed
Search for more literature for 6.3.3.2

Cloned(Commentary)

Cloned (Comment) Organism
cytsolic enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-Formyltetrahydrohomofolate most potent inhibitor Homo sapiens
5-methyltetrahydrofolate competitive with respect to 5-formyltetrahydrofolate Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0006
-
 (6S)-5-formyltetrahydropteroyl-pentaglutamate cytosolic enzyme Homo sapiens
0.0008
-
 (6S)-5-formyltetrahydropteroyl pentaglutamate mitochondrial enzyme Homo sapiens
0.002
-
 (6S)-5-formyltetrahydrofolate
-
 Homo sapiens
0.0044
-
 (6R,S)-5-formyltetrahydropteroyl-Glu cytosolic enzyme Homo sapiens
0.0047
-
 (6R,S)-5-formyltetrahydropteroyl-Glu mitochondrial enzyme Homo sapiens
0.02
-
 ATP cytosolic enzyme Homo sapiens
0.022
-
 ATP mitochondrial enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
-
 Homo sapiens
27000
-
 PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Storage Stability

Storage Stability Organism
-80°C, pH 7.0, 0.1% v/v Tween 20, 10% v/v glycerol, stable for several months Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (6R,S)-5-formyltetrahydropteroyl-Glu
-
 Homo sapiens ?
-
 ?
ATP + (6S)-5-formyltetrahydropteroyl-pentaglutamate
-
 Homo sapiens ?
-
 ?
ATP + 5-formyltetrahydrofolate
-
 Homo sapiens ADP + phosphate + 5,10-methylenetetrahydrofolate
-
 ?
ATP + 5-formyltetrahydropteroyl-pentaglutamate
-
 Homo sapiens ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 cytosolic enzyme Homo sapiens