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Literature summary for 6.3.2.51 extracted from
- Selective inhibitors of bacterial phosphopantothenoylcysteine synthetase (2009), J. Am. Chem. Soc., 131, 16340-16341.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | - |
Enterococcus faecalis |  |
| 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | - |
Escherichia coli | |
| 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | - |
Homo sapiens | |
| 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | - |
Streptococcus pneumoniae | |
| 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | - |
Enterococcus faecalis | |
| 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | - |
Escherichia coli | |
| 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | - |
Homo sapiens | |
| 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | - |
Streptococcus pneumoniae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + (R)-4'-phosphopantothenate + L-cysteine | Escherichia coli | - |
AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
| ATP + (R)-4'-phosphopantothenate + L-cysteine | Homo sapiens | - |
AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
| ATP + (R)-4'-phosphopantothenate + L-cysteine | Enterococcus faecalis | - |
AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
| ATP + (R)-4'-phosphopantothenate + L-cysteine | Streptococcus pneumoniae | - |
AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterococcus faecalis | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Streptococcus pneumoniae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + (R)-4'-phosphopantothenate + L-cysteine | - |
Escherichia coli | AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
| ATP + (R)-4'-phosphopantothenate + L-cysteine | - |
Homo sapiens | AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
| ATP + (R)-4'-phosphopantothenate + L-cysteine | - |
Enterococcus faecalis | AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
| ATP + (R)-4'-phosphopantothenate + L-cysteine | - |
Streptococcus pneumoniae | AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
| CTP + (R)-4'-phosphopantothenate + L-cysteine | - |
Escherichia coli | CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
| CTP + (R)-4'-phosphopantothenate + L-cysteine | - |
Homo sapiens | CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
| CTP + (R)-4'-phosphopantothenate + L-cysteine | - |
Enterococcus faecalis | CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
| CTP + (R)-4'-phosphopantothenate + L-cysteine | - |
Streptococcus pneumoniae | CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CoaB | - |
Escherichia coli |
| CoaB | - |
Homo sapiens |
| CoaB | - |
Enterococcus faecalis |
| CoaB | - |
Streptococcus pneumoniae |
| phosphopantothenoylcysteine synthetase | - |
Escherichia coli |
| phosphopantothenoylcysteine synthetase | - |
Homo sapiens |
| phosphopantothenoylcysteine synthetase | - |
Enterococcus faecalis |
| phosphopantothenoylcysteine synthetase | - |
Streptococcus pneumoniae |
| PPCS | - |
Escherichia coli |
| PPCS | - |
Homo sapiens |
| PPCS | - |
Enterococcus faecalis |
| PPCS | - |
Streptococcus pneumoniae |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00001 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | |
| 0.000065 | - |
pH and temperature not specified in the publication | Enterococcus faecalis | 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | |
| 0.000068 | - |
pH and temperature not specified in the publication | Escherichia coli | 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | |
| 0.003 | - |
pH and temperature not specified in the publication | Escherichia coli | 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | |
| 0.01 | - |
pH and temperature not specified in the publication | Homo sapiens | 5'-O-[hydroxy(3-[[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]amino]propoxy)phosphoryl]cytidine | |
| 0.013 | - |
pH and temperature not specified in the publication | Streptococcus pneumoniae | 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | |
| 0.018 | - |
pH and temperature not specified in the publication | Enterococcus faecalis | 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | |
| 2.7 | - |
pH and temperature not specified in the publication | Homo sapiens | 5'-O-[hydroxy(3-[[(4R)-2-hydroxy-5,5-dimethyl-2-oxo-1,3,2lambda5-dioxaphosphinane-4-carbonyl]amino]propoxy)phosphoryl]cytidine | |
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