Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(5-(4-fluorophenylsulfonyl)-3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)(phenyl)methanone | 77.0% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
(5-(4-nitrophenylsulfonyl)-3-phenyl-4,5,6,7-tetrahydro-1Hpyrazolo[4,3-c]pyridin-1-yl)(phenyl)methanone | 39.7% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-(4-(1-(cyclohexanecarbonyl)-3-phenyl-6,7-dihydro-1Hpyrazolo[4,3-c]pyridin-5(4H)-ylsulfonyl)phenyl)ethanone | 39.2% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-(4-(1-benzoyl-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-ylsulfonyl)phenyl)ethanone | 78.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-(cyclohexanecarbonyl)-3-phenyl-N-p-tolyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carbothioamide | 50.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-(cyclohexanecarbonyl)-3-phenyl-N-p-tolyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 40.8% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-(cyclohexanecarbonyl)-N-(4-ethoxyphenyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 48.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-(cyclohexanecarbonyl)-N-(4-fluorophenyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carbothioamide | 49.2% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-(cyclohexanecarbonyl)-N-(4-methoxyphenyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carbothioamide | 50.6% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-(cyclohexanecarbonyl)-N-(4-methoxyphenyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 38.7% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-(cyclohexanecarbonyl)-N-(4-nitrophenyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carbothioamide | 47.3% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-(cyclohexanecarbonyl)-N-(naphthalen-1-yl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 50.9% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-(yclohexanecarbonyl)-N-(4-nitrophenyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 50.8% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-benzoyl-3-phenyl-N-p-tolyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carbothioamide | 23.9% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-benzoyl-3-phenyl-N-p-tolyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 49.4% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-benzoyl-N-(4-bromophenyl)-3-phenyl-6,7-dihydro-1Hpyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 60.6% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-benzoyl-N-(4-chlorophenyl)-3-phenyl-6,7-dihydro-1Hpyrazolo[4,3-c]pyridine-5(4H)-carbothioamide | 37.7% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-benzoyl-N-(4-chlorophenyl)-3-phenyl-6,7-dihydro-1Hpyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 40.2% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-benzoyl-N-(4-ethoxyphenyl)-3-phenyl-6,7-dihydro-1Hpyrazolo[4,3-c] pyridine-5(4H)-carboxamide | 47.2% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-benzoyl-N-(4-fluorophenyl)-3-phenyl-6,7-dihydro-1Hpyrazolo[4,3-c]pyridine-5(4H)-carbothioamide | 43.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-benzoyl-N-(4-methoxyphenyl)-3-phenyl-6,7-dihydro-1Hpyrazolo[4,3-c]pyridine-5(4H)-carbothioamide | 10.2% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-benzoyl-N-(4-nitrophenyl)-3-phenyl-6,7-dihydro-1Hpyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 95.7% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-benzoyl-N-(naphthalen-1-yl)-3-phenyl-6,7-dihydro-1Hpyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 89.8% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-benzoyl-N-benzyl-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carbothioamide | 52.1% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-benzoyl-N-benzyl-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 46.2% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
1-benzoyl-N-isopropyl-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 40.9% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
5-tert-butyl-N-[1-(naphthalen-1-ylmethyl)-1H-pyrazol-4-yl]-4,5,6,7-tetrahydro-1,2-benzoxazole-3-carboxamide | - |
Mycobacterium tuberculosis | |
actinomycin D | - |
Mycobacterium tuberculosis | |
cyclohexyl(3-phenyl-5-(thiophen-2-ylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)methanone | 52.0% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
cyclohexyl(3-phenyl-5-tosyl-4,5,6,7-tetrahydro-1Hpyrazolo[4,3-c]pyridin-1-yl)methanone | 41.6% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
cyclohexyl(5-(4-fluorophenylsulfonyl)-3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)methanone | 46.8% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
cyclohexyl(5-(4-nitrophenylsulfonyl)-3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)methanone | 50.2% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
methyl 5-amino-3-(benzyloxy)-1H-indole-2-carboxylate | - |
Mycobacterium tuberculosis | |
additional information | synthesis and evaluation of 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as pantothenate synthetase inhibitors, overview. No inhibition by isoniazid and ethambutol | Mycobacterium tuberculosis | |
N-(4-acetylphenyl)-1-(cyclohexanecarbonyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 51.4% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
N-(4-acetylphenyl)-1-benzoyl-3-phenyl-6,7-dihydro-1Hpyrazolo[4,3-c] pyridine-5(4H)-carboxamide | 43.7% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
N-(4-bromophenyl)-1-(cyclohexanecarbonyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 50.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
N-(4-chlorophenyl)-1-(cyclohexanecarbonyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carbothioamide | 56.3% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
N-(4-chlorophenyl)-1-(cyclohexanecarbonyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 54.7% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
N-allyl-1-benzoyl-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carbothioamide | 41.7% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
N-benzyl-1-(cyclohexanecarbonyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carbothioamide | 51.4% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
N-benzyl-1-(cyclohexanecarbonyl)-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxamide | 49.1% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
nafronyl oxalate | - |
Mycobacterium tuberculosis | |
phenyl(3-phenyl-5-(thiophen-2-ylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)methanone | 48.7% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
phenyl(3-phenyl-5-tosyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)methanone | 9.0% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
[2-[(1-benzofuran-2-ylsulfonyl)carbamoyl]-5-methyl-1H-inden-1-yl]acetic acid | - |
Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WIL5 | gene panC, locus Rv3602c | - |
Mycobacterium tuberculosis H37Rv | P9WIL5 | gene panC, locus Rv3602c | - |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
Pantothenate synthetase | - |
Mycobacterium tuberculosis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00009 | - |
5-tert-butyl-N-[1-(naphthalen-1-ylmethyl)-1H-pyrazol-4-yl]-4,5,6,7-tetrahydro-1,2-benzoxazole-3-carboxamide | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
0.0018 | - |
[2-[(1-benzofuran-2-ylsulfonyl)carbamoyl]-5-methyl-1H-inden-1-yl]acetic acid | pH and temperature not specified in the publication | Mycobacterium tuberculosis | |
0.0224 | - |
methyl 5-amino-3-(benzyloxy)-1H-indole-2-carboxylate | pH and temperature not specified in the publication | Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0218 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1-benzoyl-N-(4-nitrophenyl)-3-phenyl-6,7-dihydro-1Hpyrazolo[4,3-c]pyridine-5(4H)-carboxamide | |
0.0382 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1-benzoyl-N-(naphthalen-1-yl)-3-phenyl-6,7-dihydro-1Hpyrazolo[4,3-c]pyridine-5(4H)-carboxamide | |
0.0386 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | (5-(4-fluorophenylsulfonyl)-3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-1-yl)(phenyl)methanone | |
0.0391 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1-(4-(1-benzoyl-3-phenyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-ylsulfonyl)phenyl)ethanone | |
0.0821 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 1-benzoyl-N-(4-bromophenyl)-3-phenyl-6,7-dihydro-1Hpyrazolo[4,3-c]pyridine-5(4H)-carboxamide | |
0.2507 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | actinomycin D |