Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli Tuner (DE3) cells | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cladosporin | 30% inhibition at 0.11 mM | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-lysine + tRNALys | Plasmodium falciparum | - |
AMP + diphosphate + L-lysyl-tRNALys | - |
? | |
ATP + L-lysine + tRNALys | Plasmodium falciparum FCB | - |
AMP + diphosphate + L-lysyl-tRNALys | - |
? | |
ATP + L-lysine + tRNALys | Plasmodium falciparum NF54 | - |
AMP + diphosphate + L-lysyl-tRNALys | - |
? | |
ATP + L-lysine + tRNALys | Plasmodium falciparum Camp R | - |
AMP + diphosphate + L-lysyl-tRNALys | - |
? | |
ATP + L-lysine + tRNALys | Plasmodium falciparum FCR3 | - |
AMP + diphosphate + L-lysyl-tRNALys | - |
? | |
ATP + L-lysine + tRNALys | Plasmodium falciparum D1 | - |
AMP + diphosphate + L-lysyl-tRNALys | - |
? | |
ATP + L-lysine + tRNALys | Plasmodium falciparum D6 | - |
AMP + diphosphate + L-lysyl-tRNALys | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Plasmodium falciparum Camp R | - |
- |
- |
Plasmodium falciparum D1 | - |
- |
- |
Plasmodium falciparum D6 | - |
- |
- |
Plasmodium falciparum FCB | - |
- |
- |
Plasmodium falciparum FCR3 | - |
- |
- |
Plasmodium falciparum NF54 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-affinity column chromatography, and MonoQ column chromatography | Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-lysine + tRNALys | - |
Plasmodium falciparum | AMP + diphosphate + L-lysyl-tRNALys | - |
? | |
ATP + L-lysine + tRNALys | - |
Plasmodium falciparum FCB | AMP + diphosphate + L-lysyl-tRNALys | - |
? | |
ATP + L-lysine + tRNALys | - |
Plasmodium falciparum NF54 | AMP + diphosphate + L-lysyl-tRNALys | - |
? | |
ATP + L-lysine + tRNALys | - |
Plasmodium falciparum Camp R | AMP + diphosphate + L-lysyl-tRNALys | - |
? | |
ATP + L-lysine + tRNALys | - |
Plasmodium falciparum FCR3 | AMP + diphosphate + L-lysyl-tRNALys | - |
? | |
ATP + L-lysine + tRNALys | - |
Plasmodium falciparum D1 | AMP + diphosphate + L-lysyl-tRNALys | - |
? | |
ATP + L-lysine + tRNALys | - |
Plasmodium falciparum D6 | AMP + diphosphate + L-lysyl-tRNALys | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KRS | - |
Plasmodium falciparum |
Lysyl-tRNA synthetase | - |
Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000454 | - |
in 40 mM HEPES (pH 7.5), at 22°C | Plasmodium falciparum | cladosporin | |
0.0000574 | - |
in 40 mM HEPES (pH 7.5), at 22°C | Plasmodium falciparum | cladosporin | |
0.0000667 | - |
in 40 mM HEPES (pH 7.5), at 22°C | Plasmodium falciparum | cladosporin | |
0.0000721 | - |
in 40 mM HEPES (pH 7.5), at 22°C | Plasmodium falciparum | cladosporin | |
0.0000779 | - |
in 40 mM HEPES (pH 7.5), at 22°C | Plasmodium falciparum | cladosporin | |
0.0000801 | - |
in 40 mM HEPES (pH 7.5), at 22°C | Plasmodium falciparum | cladosporin | |
0.0000879 | - |
in 40 mM HEPES (pH 7.5), at 22°C | Plasmodium falciparum | cladosporin | |
0.0000896 | - |
in 40 mM HEPES (pH 7.5), at 22°C | Plasmodium falciparum | cladosporin |