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Literature summary for 6.1.1.2 extracted from
- Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models (2007), Neuromolecular Med., 9, 55-82.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell models, overview | Homo sapiens | |
| additional information | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, overview | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-tryptophan | product inhibition at physiologic concentrations | Homo sapiens |  |
| L-tryptophan | product inhibition at physiologic concentrations | Mus musculus | |
| tryptamine | a metabolic tryptophan analog that acts as a potent competitive inhibitor of TrpRS, overview | Homo sapiens | |
| tryptamine | a metabolic tryptophan analog that acts as a potent competitive inhibitor of TrpRS, overview | Mus musculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus | |
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-tryptophan + tRNATrp | Mus musculus | - |
AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? | |
| ATP + L-tryptophan + tRNATrp | Homo sapiens | - |
AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? | |
| ATP + L-tryptophan + tRNATrp | Mus musculus BALB/c | - |
AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? | |
| additional information | Homo sapiens | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview | ? | - |
? | |
| additional information | Mus musculus | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview | ? | - |
? | |
| additional information | Mus musculus BALB/c | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
Balb/c mice | - |
| Mus musculus BALB/c | - |
Balb/c mice | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| neuron | - |
Mus musculus | - |
| SH-SY5Y cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-tryptophan + tRNATrp | - |
Mus musculus | AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? | |
| ATP + L-tryptophan + tRNATrp | - |
Homo sapiens | AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? | |
| ATP + L-tryptophan + tRNATrp | - |
Mus musculus BALB/c | AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? | |
| additional information | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview | Homo sapiens | ? | - |
? | |
| additional information | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview | Mus musculus | ? | - |
? | |
| additional information | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview | Mus musculus BALB/c | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | TrpRS N-terminal peptide self-assembles in double-helical fibrils in vitro | Mus musculus |
| More | TrpRS N-terminal peptide self-assembles in double-helical fibrils in vitro | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TrpRS | - |
Mus musculus |
| TrpRS | - |
Homo sapiens |
| Tryptophanyl-tRNA synthetase | - |
Mus musculus |
| Tryptophanyl-tRNA synthetase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Mus musculus |
| 7.5 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
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