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Literature summary for 5.6.1.7 extracted from

  • Seixas, C.; Cruto, T.; Tavares, A.; Gaertig, J.; Soares, H.
    CCTalpha and CCTdelta chaperonin subunits are essential and required for cilia assembly and maintenance in Tetrahymena (2010), PLoS ONE, 5, e10704.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.1.7

Protein Variants

Protein Variants Comment Organism
G346 mutation in CCTalpha causes defects in cilia and impaires CCTalpha localization in cilia Tetrahymena thermophila

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Tetrahymena thermophila 5829
-

Organism

Organism UniProt Comment Textmining
Tetrahymena thermophila
-
-
-

Subunits

Subunits Comment Organism
heterooligomer complex formed by two rings connected back-to-back, each composed of eight distinct subunits (CCTalpha to CCTzeta) Tetrahymena thermophila

Synonyms

Synonyms Comment Organism
chaperonin CCT
-
 Tetrahymena thermophila

General Information

General Information Comment Organism
malfunction cells lacking the zygotic expression of either CCTalpha or CCTdelta show a loss of cell body microtubules, fail to assemble new cilia and die within 2 cell cycles. Loss of CCT subunit activity leads to axoneme shortening and splaying of tips of axonemal microtubules. An epitope-tagged CCTa rescued the gene knockout phenotype and localizes primarily to the tips of cilia Tetrahymena thermophila
physiological function the CCT subunits are essential and required for ciliary assembly and maintenance of axoneme structure, especially at the tips of cilia. The enzyme mediates the folding, of a wide range of newly synthesized proteins including tubulin (alpha, beta and gamma) and actin, as quantitatively major substrates Tetrahymena thermophila