Any feedback?
Literature summary for 5.6.1.1 extracted from
- Identification of katanin, an ATPase that severs and disassembles stable microtubules (1993), Cell, 75, 419-429.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Chlamydomonas reinhardtii |  |
| ADP | inhibits both ATPase and severing activities | Strongylocentrotus purpuratus | |
| ATPgammaS | - |
Chlamydomonas reinhardtii | |
| ATPgammaS | - |
Strongylocentrotus purpuratus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Chlamydomonas reinhardtii | 5737 | - |
| cytoplasm | - |
Strongylocentrotus purpuratus | 5737 | - |
| cytoplasm | - |
Actinocoryne sp. | 5737 | - |
| endoplasmic reticulum | - |
Chlamydomonas reinhardtii | 5783 | - |
| endoplasmic reticulum | - |
Strongylocentrotus purpuratus | 5783 | - |
| endoplasmic reticulum | - |
Actinocoryne sp. | 5783 | - |
| Golgi apparatus | - |
Chlamydomonas reinhardtii | 5794 | - |
| Golgi apparatus | - |
Strongylocentrotus purpuratus | 5794 | - |
| Golgi apparatus | - |
Actinocoryne sp. | 5794 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
gel filtration | Strongylocentrotus purpuratus |
| 81000 | - |
gel filtration | Strongylocentrotus purpuratus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | Chlamydomonas reinhardtii | - |
ADP + phosphate | - |
? | |
| ATP + H2O | Xenopus laevis | - |
ADP + phosphate | - |
? | |
| ATP + H2O | Spisula solidissima | - |
ADP + phosphate | - |
? | |
| ATP + H2O | Strongylocentrotus purpuratus | - |
ADP + phosphate | - |
? | |
| ATP + H2O | Actinocoryne sp. | - |
ADP + phosphate | - |
? | |
| GTP + H2O | Chlamydomonas reinhardtii | - |
GDP + phosphate | - |
? | |
| GTP + H2O | Xenopus laevis | - |
GDP + phosphate | - |
? | |
| GTP + H2O | Spisula solidissima | - |
GDP + phosphate | - |
? | |
| GTP + H2O | Strongylocentrotus purpuratus | - |
GDP + phosphate | - |
? | |
| GTP + H2O | Actinocoryne sp. | - |
GDP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Actinocoryne sp. | - |
- |
- |
| Chlamydomonas reinhardtii | - |
- |
- |
| Spisula solidissima | - |
- |
- |
| Strongylocentrotus purpuratus | - |
sea urchin | - |
| Xenopus laevis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| copurification of p81 and p60 | Strongylocentrotus purpuratus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome | Chlamydomonas reinhardtii | |
| n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome | Xenopus laevis | |
| n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome | Spisula solidissima | |
| n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome | Strongylocentrotus purpuratus | |
| n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers | another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome | Actinocoryne sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Chlamydomonas reinhardtii | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Xenopus laevis | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Spisula solidissima | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Strongylocentrotus purpuratus | ADP + phosphate | - |
? | |
| ATP + H2O | - |
Actinocoryne sp. | ADP + phosphate | - |
? | |
| GTP + H2O | - |
Chlamydomonas reinhardtii | GDP + phosphate | - |
? | |
| GTP + H2O | - |
Xenopus laevis | GDP + phosphate | - |
? | |
| GTP + H2O | - |
Spisula solidissima | GDP + phosphate | - |
? | |
| GTP + H2O | - |
Strongylocentrotus purpuratus | GDP + phosphate | - |
? | |
| GTP + H2O | - |
Actinocoryne sp. | GDP + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Chlamydomonas reinhardtii |
| dimer | - |
Xenopus laevis |
| dimer | - |
Actinocoryne sp. |
| dimer | 1 * 81000 + 1 * 60000, SDS-PAGE | Strongylocentrotus purpuratus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| microtubule-stimulated ATPase | - |
Strongylocentrotus purpuratus |
| p81-p60 | - |
Strongylocentrotus purpuratus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
