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Literature summary for 5.4.3.6 extracted from

  • Wu, B.; Szymanski, W.; Wijma, H.J.; Crismaru, C.G.; de Wildeman, S.; Poelarends, G.J.; Feringa, B.L.; Janssen, D.B.
    Engineering of an enantioselective tyrosine aminomutase by mutation of a single active site residue in phenylalanine aminomutase (2010), Chem. Commun. (Camb. ), 46, 8157-8159.
    View publication on PubMed
Search for more literature for 5.4.3.6

Protein Variants

Protein Variants Comment Organism
C107F inactive Chondromyces crocatus
C107F inactive Streptomyces globisporus
C107F inactive Cupriavidus crocatus
H93F the mutation abolishes all enzymatic activity Chondromyces crocatus
H93F the mutation abolishes all enzymatic activity Streptomyces globisporus
H93F the mutation abolishes all enzymatic activity Cupriavidus crocatus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.028
-
 L-tyrosine pH and temperature not specified in the publication Streptomyces globisporus
0.377
-
 L-tyrosine pH and temperature not specified in the publication Chondromyces crocatus
0.377
-
 L-tyrosine pH and temperature not specified in the publication Cupriavidus crocatus

Organism

Organism UniProt Comment Textmining
Chondromyces crocatus
-
-
-
Cupriavidus crocatus
-
-
-
Streptomyces globisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine
-
 Chondromyces crocatus (R)-beta-tyrosine preferred product r
L-tyrosine
-
 Cupriavidus crocatus (R)-beta-tyrosine preferred product r
L-tyrosine
-
 Streptomyces globisporus (S)-beta-tyrosine preferred product r
additional information L-phenylalanine is no substrate Chondromyces crocatus ?
-
 ?
additional information L-phenylalanine is no substrate Streptomyces globisporus ?
-
 ?
additional information L-phenylalanine is no substrate Cupriavidus crocatus ?
-
 ?

Synonyms

Synonyms Comment Organism
TAM
-
 Chondromyces crocatus
TAM
-
 Streptomyces globisporus
TAM
-
 Cupriavidus crocatus
tyrosine aminomutase
-
 Chondromyces crocatus
tyrosine aminomutase
-
 Streptomyces globisporus
tyrosine aminomutase
-
 Cupriavidus crocatus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
7000
-
 L-tyrosine pH and temperature not specified in the publication Chondromyces crocatus
7000
-
 L-tyrosine pH and temperature not specified in the publication Cupriavidus crocatus
10000
-
 L-tyrosine pH and temperature not specified in the publication Streptomyces globisporus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1900
-
 L-tyrosine pH and temperature not specified in the publication Chondromyces crocatus
1900
-
 L-tyrosine pH and temperature not specified in the publication Cupriavidus crocatus
36000
-
 L-tyrosine pH and temperature not specified in the publication Streptomyces globisporus