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Literature summary for 5.4.3.6 extracted from

  • Montavon, T.J.; Christianson, C.V.; Festin, G.M.; Shen, B.; Bruner, S.D.
    Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM (2008), Bioorg. Med. Chem. Lett., 18, 3099-3102.
    View publication on PubMed
Search for more literature for 5.4.3.6

Inhibitors

Inhibitors Comment Organism Structure
(2S,3R)-3-(4-fluorophenyl)oxirane-2-carboxylate
-
 Streptomyces globisporus
(2S,3R)-3-(4-methoxyphenyl)oxirane-2-carboxylate
-
 Streptomyces globisporus
(2S,3R)-3-phenyloxirane-2-carboxylate
-
 Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-(4-hydroxyphenyl)propanoate
-
 Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-(4-methoxyphenyl)propanoate
-
 Streptomyces globisporus
(3R)-3-ammonio-2,2-difluoro-3-phenylpropanoate
-
 Streptomyces globisporus

Organism

Organism UniProt Comment Textmining
Streptomyces globisporus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine
-
 Streptomyces globisporus 3-amino-3-(4-hydroxyphenyl)propanoate
-
 ?

Synonyms

Synonyms Comment Organism
TAM
-
 Streptomyces globisporus
tyrosine aminomutase
-
 Streptomyces globisporus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3
-
-
 Streptomyces globisporus (2S,3R)-3-(4-methoxyphenyl)oxirane-2-carboxylate
4.8
-
-
 Streptomyces globisporus (3R)-3-ammonio-2,2-difluoro-3-(4-hydroxyphenyl)propanoate
5.3
-
-
 Streptomyces globisporus (3R)-3-ammonio-2,2-difluoro-3-(4-methoxyphenyl)propanoate
5.8
-
-
 Streptomyces globisporus (2S,3R)-3-phenyloxirane-2-carboxylate
7.3
-
-
 Streptomyces globisporus (3R)-3-ammonio-2,2-difluoro-3-phenylpropanoate
11.6
-
-
 Streptomyces globisporus (2S,3R)-3-(4-fluorophenyl)oxirane-2-carboxylate