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Literature summary for 5.4.2.9 extracted from
- Interaction of inhibitors with phosphoenolpyruvate mutase: implications for the reaction mechanism and the nature of the active site (1994), Biochemistry, 33, 5641-5646.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Br- | noncompetitive | Tetrahymena pyriformis |  |
| Cl- | noncompetitive | Tetrahymena pyriformis | |
| H2PO2- | noncompetitive | Tetrahymena pyriformis | |
| HCO2- | noncompetitive | Tetrahymena pyriformis | |
| HCO3- | noncompetitive | Tetrahymena pyriformis | |
| HPO32- | competitive | Tetrahymena pyriformis | |
| I- | noncompetitive | Tetrahymena pyriformis | |
| isocitrate analogues | - |
Tetrahymena pyriformis | |
| NO2- | noncompetitive | Tetrahymena pyriformis | |
| NO3- | noncompetitive | Tetrahymena pyriformis | |
| oxalate | synergistic inhibition in combination with a small noncompetitive inhibitor | Tetrahymena pyriformis | |
| PO43- | competitive | Tetrahymena pyriformis | |
| SO32- | noncompetitive | Tetrahymena pyriformis | |
| SO42- | competitive | Tetrahymena pyriformis | |
| VO43- | competitive | Tetrahymena pyriformis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
Phosphonopyruvate | pH 7.5 | Tetrahymena pyriformis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces hygroscopicus | - |
- |
- |
| Tetrahymena pyriformis | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| phosphoenolpyruvate = 3-phosphonopyruvate | mechanism | Tetrahymena pyriformis | |
| phosphoenolpyruvate = 3-phosphonopyruvate | mechanism | Streptomyces hygroscopicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate | - |
Tetrahymena pyriformis | 3-phosphonopyruvate | - |
? | |
| phosphoenolpyruvate | - |
Streptomyces hygroscopicus | 3-phosphonopyruvate | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 150 | - |
Phosphonopyruvate | pH 7.5 | Tetrahymena pyriformis | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.025 | - |
oxalate | pH 7.5 | Tetrahymena pyriformis | |
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