BRENDA - Enzyme Database
show all sequences of 5.3.3.6

Nicotinic acid metabolism. VII. Mechanism of action of Clostridial alpha-methyleneglutarate mutase (B12-dependent) and methylitaconate isomerase

Kung, H.F.; Tsai, L.; J. Biol. Chem. 246, 6436-6443 (1971) View publication on PubMed

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
Methylitaconate
Eubacterium barkeri
key step in the overall fermentation of nicotinate
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Eubacterium barkeri
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
culture condition:nicotinic acid-grown cell
not detectable in cells grown on glucose
Eubacterium barkeri
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
Methylitaconate
r
2986
Eubacterium barkeri
Dimethylmaleate
-
2986
Eubacterium barkeri
?
Methylitaconate
formation of dimethylmaleate is favored
2986
Eubacterium barkeri
Dimethylmaleate
-
2986
Eubacterium barkeri
?
Methylitaconate
key step in the overall fermentation of nicotinate
2986
Eubacterium barkeri
?
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
Methylitaconate
Eubacterium barkeri
key step in the overall fermentation of nicotinate
?
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
culture condition:nicotinic acid-grown cell
not detectable in cells grown on glucose
Eubacterium barkeri
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
Methylitaconate
r
2986
Eubacterium barkeri
Dimethylmaleate
-
2986
Eubacterium barkeri
?
Methylitaconate
formation of dimethylmaleate is favored
2986
Eubacterium barkeri
Dimethylmaleate
-
2986
Eubacterium barkeri
?
Methylitaconate
key step in the overall fermentation of nicotinate
2986
Eubacterium barkeri
?
-
-
-
?
Other publictions for EC 5.3.3.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
705153
Velarde
Crystal structure and putative ...
Eubacterium barkeri
J. Mol. Biol.
391
609-620
2009
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1
1
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2
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3
1
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11
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1
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1
2
1
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2
1
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1
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2
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1
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1
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2
1
1
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2
1
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1
1
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-
670692
Alhapel
Molecular and functional analy ...
Eubacterium barkeri
Proc. Natl. Acad. Sci. USA
103
12341-12346
2006
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1
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1
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1
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2988
Hartrampf
On the steric course of the ad ...
Eubacterium barkeri
Eur. J. Biochem.
156
301-304
1986
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1
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1
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2986
Kung
Nicotinic acid metabolism. VII ...
Eubacterium barkeri
J. Biol. Chem.
246
6436-6443
1971
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-
-
-
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-
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1
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1
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1
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3
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1
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1
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3
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3522
Kung
Nicotinic acid metabolism. VI. ...
Eubacterium barkeri
J. Biol. Chem.
246
3378-3388
1971
3
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3
2
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1
1
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1
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1
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1
3
1
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1
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3
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3
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2
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1
1
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1
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1
3
1
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1
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