Cloned (Comment) | Organism |
---|---|
expressed in the Saccharomyces cerevisiae mutant erg2 | Zea mays |
Protein Variants | Comment | Organism |
---|---|---|
D107V | inactive | Zea mays |
E116V | mutant exhibits 72% of wild type activity | Saccharomyces cerevisiae |
E121V | inactive | Zea mays |
E73V | mutant exhibits 100% of wild type activity | Saccharomyces cerevisiae |
E78V | inactive | Zea mays |
H69L | mutant exhibits 70% of wild type activity | Saccharomyces cerevisiae |
H74L | inactive | Zea mays |
T119I | inactive | Saccharomyces cerevisiae |
T124I | mutant exhibits 10% of wild type activity | Zea mays |
W193L | inactive | Zea mays |
W66L | inactive | Zea mays |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AY9944 | - |
Zea mays | |
fenpropimorph | - |
Saccharomyces cerevisiae | |
fenpropimorph | - |
Zea mays | |
additional information | not inhibited by N-benzamido-decalin, tamoxifen, N-benzyl-8-azadecalin, and AY9944 | Saccharomyces cerevisiae | |
additional information | not inhibited by N-benzamido-decalin | Zea mays | |
SR31747 | - |
Saccharomyces cerevisiae | |
SR31747 | - |
Zea mays | |
tamoxifen | - |
Zea mays | |
tridemorph | - |
Saccharomyces cerevisiae | |
tridemorph | - |
Zea mays | |
Trifluoperazine | - |
Saccharomyces cerevisiae | |
Trifluoperazine | - |
Zea mays |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.116 | - |
stigmasta-8-en-3beta-ol | - |
Zea mays | |
0.512 | - |
cholesta-8,24-dien-3beta-ol | - |
Zea mays | |
0.522 | - |
4alpha-methyl-ergosta-8,24-dien-3beta-ol | - |
Zea mays |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Zea mays | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4alpha-methyl-ergosta-8,24-dien-3beta-ol | - |
Zea mays | ? | - |
? | |
4alpha-methyl-fecosterol | - |
Zea mays | 4alpha-methyl-ergosta-7,24-dien-3beta-ol | - |
? | |
cholesta-8,24-dien-3beta-ol | - |
Zea mays | ? | - |
? | |
DELTA8-sitostenol | - |
Zea mays | stigmast-7-en-3beta-ol | - |
? | |
additional information | 4,4-dimethyl-cholesta-8,24-dien-3beta-ol, 4,4-dimethyl-ergosta-8,24-dien-3beta-ol, 4alpha,14aloha-dimethyl-ergosta-8,24-dien-3beta-ol, and cholest-8(14)-en-3beta-ol are no substrates | Zea mays | ? | - |
? | |
stigmasta-8-en-3beta-ol | - |
Zea mays | ? | - |
? | |
zymosterol | - |
Saccharomyces cerevisiae | cholesta-7,24-dienol | - |
? | |
zymosterol | - |
Zea mays | cholesta-7,24-dienol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
8,7SI | - |
Saccharomyces cerevisiae |
8,7SI | - |
Zea mays |
EBP | - |
Zea mays |
ERG2p | - |
Saccharomyces cerevisiae |
sterol 8,7-isomerase | - |
Saccharomyces cerevisiae |
sterol 8,7-isomerase | - |
Zea mays |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00003 | - |
- |
Saccharomyces cerevisiae | fenpropimorph | |
0.0001 | - |
- |
Zea mays | AY9944 | |
0.0001 | - |
- |
Zea mays | SR31747 | |
0.00021 | - |
- |
Zea mays | fenpropimorph | |
0.0006 | - |
- |
Saccharomyces cerevisiae | SR31747 | |
0.00085 | - |
- |
Zea mays | tridemorph | |
0.001 | - |
- |
Zea mays | Trifluoperazine | |
0.001 | - |
- |
Saccharomyces cerevisiae | tridemorph | |
0.0085 | - |
- |
Zea mays | tamoxifen | |
0.5 | - |
IC50 above 0.5 mM | Saccharomyces cerevisiae | Trifluoperazine |