Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dTDP-4-dehydro-6-deoxy-D-glucose | Komagataeibacter xylinus | the enzyme is involved in the dTDP-rhamnose synthesis pathway which consists of three steps: (i) the synthesis of dTDP-4-keto-6-deoxy-D-glucose from glucose 1-phosphate and dTDP, (ii) the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-4-keto-L-rhamnose by dTDP-4-dehydrorhamnose 3,5-epimerase and (iii) the reduction of dTDP-4-keto-L-rhamnose to dTDP-L-rhamnose. The mutant K3 strain, with a spontaneous mutation that results in lower cellulose production, shows deoxythymidine diphosphate-4-dehydrorhamnose 3,5-epimerase activity, while the wild-type does not, determined by 2D-gel electrophoresis. It is possible that in the wild-type, transcription of the gene responsible for the expression of dTDP-4-dehydrorhamnose 3,5-epimerase is repressed by a transcription factor, and that a mutation in the gene encoding the transcription factor has rendered it non-functional | dTDP-4-dehydro-L-rhamnose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Komagataeibacter xylinus | - |
mutant strain K3, isolated from Kombucha, Kombu Australia, Springwood, Queensland, Australia | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dTDP-4-dehydro-6-deoxy-D-glucose | - |
Komagataeibacter xylinus | dTDP-4-dehydro-L-rhamnose | - |
? | |
dTDP-4-dehydro-6-deoxy-D-glucose | the enzyme is involved in the dTDP-rhamnose synthesis pathway which consists of three steps: (i) the synthesis of dTDP-4-keto-6-deoxy-D-glucose from glucose 1-phosphate and dTDP, (ii) the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-4-keto-L-rhamnose by dTDP-4-dehydrorhamnose 3,5-epimerase and (iii) the reduction of dTDP-4-keto-L-rhamnose to dTDP-L-rhamnose. The mutant K3 strain, with a spontaneous mutation that results in lower cellulose production, shows deoxythymidine diphosphate-4-dehydrorhamnose 3,5-epimerase activity, while the wild-type does not, determined by 2D-gel electrophoresis. It is possible that in the wild-type, transcription of the gene responsible for the expression of dTDP-4-dehydrorhamnose 3,5-epimerase is repressed by a transcription factor, and that a mutation in the gene encoding the transcription factor has rendered it non-functional | Komagataeibacter xylinus | dTDP-4-dehydro-L-rhamnose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
deoxythymidine diphosphate-4-dehydrorhamnose 3,5-epimerase | - |
Komagataeibacter xylinus |
dTDP-4-dehydrorhamnose 3,5-epimerase | - |
Komagataeibacter xylinus |
General Information | Comment | Organism |
---|---|---|
metabolism | dTDP-4-dehydrorhamnose 3,5-epimerase is an enzyme which may be associated with the cellulose synthesis-reducing effect of the mutation in strain K3 | Komagataeibacter xylinus |