Literature summary for 4.6.1.2 extracted from

Kollau, A.; Opelt, M.; Woelkart, G.; Gorren, A.C.F.; Russwurm, M.; Koesling, D.; Mayer, B.; Schrammel, A.
Irreversible activation and stabilization of soluble guanylate cyclase by the protoporphyrin IX mimetic cinaciguat (2018), Mol. Pharmacol., 93, 73-78 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
cinaciguat	cinaciguat activates the heme-free enzyme in a concentration-dependent manner with an EC50 value of about 0.2 microM and maximal cGMP formation at 10 microM. The compound causes time- and concentration-dependent relaxation of precontracted vessels with a maximal effect observed at 90 minutes. The dilatory response is not affected by extensive washout of the drug. Cinaciguat-induced vasodilation is associated with a time- and concentration-dependent increase of cGMP levels. The effect of cinaciguat on 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one-oxidized (ferric) soluble guanylate cyclase is moderate, reaching about 10%-15% of maximal activity	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
artery	coronary artery	Sus scrofa	-

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Release 2023.1 (January 2023)