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Literature summary for 4.6.1.2 extracted from

  • Hartmann, M.; Skryabin, B.V.; Mueller, T.; Gazinski, A.; Schroeter, J.; Gassner, B.; Nikolaev, V.O.; Buenemann, M.; Kuhn, M.
    Alternative splicing of the guanylyl cyclase-A receptor modulates atrial natriuretic peptide signaling (2008), J. Biol. Chem., 283, 28313-28320.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
atrial natriuretic peptide
-
 Mus musculus
B-type natriuretic peptide
-
 Mus musculus
additional information treatment of mice with angiotensin II results in enhanced pulmonary mRNA expression of spliced GC-A, which is concomitant to diminished GC-A/cGMP responses to atrial natriuretic peptide, overview Mus musculus

Application

Application Comment Organism
pharmacology alternative splicing can regulate endogenous ANP/GC-A signaling, thus, angiotensin II-induced alternative splicing of GC-A may represent a mechanism for reducing the sensitivity to atrial natriuretic peptide Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
cloning of isozyme GC-A, DNA and amino acid sequence determination, analysis, and quantitative expression analysis, expression of FLAG-tagged or HA-tagged wild-type GC-A and of mutant GC-ADELTALys314-Gln330 and in HEK-293 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of a mutant GC-ADELTALys314-Gln330 and transfection into HEK-293 cells leading to complete inhibition of binding of atrial natriuretic peptide and atrial natriuretic peptide-induced cyclic GMP formation, overview. Alternative splicing does not affect membrane localization of GC-A, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane transmembrane isozyme GC-A Mus musculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mus musculus the homodimeric transmembrane guanylyl cyclase-A receptor produces cytoplasmic cyclic GMP from GTP on binding its extracellular ligands, atrial and B-type natriuretic peptides, which modulate blood pressure and volume through the stimulation of cyclic GMP production by their guanylyl cyclase-A receptor, overview. Alternative splicing can regulate endogenous ANP/GC-A signaling, overview 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P18293 129/Sv and C57BL/6 strain hybrids, isozyme GC-A
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?
GTP the homodimeric transmembrane guanylyl cyclase-A receptor produces cytoplasmic cyclic GMP from GTP on binding its extracellular ligands, atrial and B-type natriuretic peptides, which modulate blood pressure and volume through the stimulation of cyclic GMP production by their guanylyl cyclase-A receptor, overview. Alternative splicing can regulate endogenous ANP/GC-A signaling, overview Mus musculus 3',5'-cyclic GMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
homodimer
-
 Mus musculus

Synonyms

Synonyms Comment Organism
GC-A
-
 Mus musculus
guanylyl cyclase-A receptor
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus