Activating Compound | Comment | Organism | Structure |
---|---|---|---|
forskolin | increases the number of active synapses | Mus musculus | |
forskolin | increases the number of active synapses | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | in cells from mice doubly deficient in isozymes AC1 and AC8, the baseline percentage of active synapses is only modestly reduced compared with wild-type synapses, and forskolin unsilencing is similar in the two genotypes, but after strong presynaptic silencing, recovery of normal function is strongly inhibited in AC1/AC8-deficient synapses, the entire recovery phenotype of the double null is reproduced in AC8-deficient but not in AC1-deficient cells, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
synapse | - |
Mus musculus | 45202 | - |
synapse | - |
Rattus norvegicus | 45202 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | isozymes AC1 and AC8 are the major Ca2+-sensitive AC isoforms, generally ubiquitous role of Ca2+ in the induction of activity-dependent synaptic plasticity | Mus musculus | |
Ca2+ | isozymes AC1 and AC8 are the major Ca2+-sensitive AC isoforms, generally ubiquitous role of Ca2+ in the induction of activity-dependent synaptic plasticity | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Mus musculus | Ca2+-dependent adenylyl cyclases play a specific role in recovery from adaptive presynaptic silencing, involvement of the cAMP pathway in the basal balance between silenced and active synapses, as well as the recovery of baseline function after depolarization-induced presynaptic silencing, e.g. by glutamate, although isozymes AC1 and AC8 are not crucial for the baseline balance between silent and active synapses, overview | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | Rattus norvegicus | Ca2+-dependent adenylyl cyclases play a specific role in recovery from adaptive presynaptic silencing, involvement of the cAMP pathway in the basal balance between silenced and active synapses, as well as the recovery of baseline function after depolarization-induced presynaptic silencing, e.g. by glutamate, although isozymes AC1 and AC8 are not crucial for the baseline balance between silent and active synapses, overview. But AC8 plays a particularly important role in rapidly resetting the balance of active to silent synapses after adaptation to strong activity | 3',5'-cyclic-AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hippocampus | - |
Mus musculus | - |
hippocampus | - |
Rattus norvegicus | - |
neuron | - |
Mus musculus | - |
neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | - |
Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | Ca2+-dependent adenylyl cyclases play a specific role in recovery from adaptive presynaptic silencing, involvement of the cAMP pathway in the basal balance between silenced and active synapses, as well as the recovery of baseline function after depolarization-induced presynaptic silencing, e.g. by glutamate, although isozymes AC1 and AC8 are not crucial for the baseline balance between silent and active synapses, overview | Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | Ca2+-dependent adenylyl cyclases play a specific role in recovery from adaptive presynaptic silencing, involvement of the cAMP pathway in the basal balance between silenced and active synapses, as well as the recovery of baseline function after depolarization-induced presynaptic silencing, e.g. by glutamate, although isozymes AC1 and AC8 are not crucial for the baseline balance between silent and active synapses, overview. But AC8 plays a particularly important role in rapidly resetting the balance of active to silent synapses after adaptation to strong activity | Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC1 | - |
Mus musculus |
AC1 | - |
Rattus norvegicus |
AC8 | - |
Mus musculus |
AC8 | - |
Rattus norvegicus |
adenylyl cyclase 1 | - |
Mus musculus |
adenylyl cyclase 1 | - |
Rattus norvegicus |
adenylyl cyclase 8 | - |
Mus musculus |
adenylyl cyclase 8 | - |
Rattus norvegicus |
Ca2+-dependent adenylyl cyclase | - |
Mus musculus |
Ca2+-dependent adenylyl cyclase | - |
Rattus norvegicus |