Application | Comment | Organism |
---|---|---|
medicine | involved in mediating opioid actions, AC5 is essential for micro, and to a lesser extent, delta, opioid receptor signaling in striatum | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | AC5-/- mice, all of the major behavioral effects of morphine, including locomotor activation, analgesia, tolerance, reward, and physical dependence and withdrawal symptoms, are attenuated. Sniffing, ptosis, teeth chattering, and body tremor are markedly reduced, diarrhea and paw tremor are not significantly different, the number of jumps is dramatically increased. Behavioral effects of selective micro or delta opioid receptor agonists are lost, behavioral effects of selective kappa opioid receptor agonists are unaffected. Loss of AC5 does not alter expression levels of opioid receptor transcripts | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
delta opioid receptor agonist DPDPE | i..e. d-Pen2,d-Pen5 enkephalin, delta opioid receptor agonist, 0.001 mM significantly represses forskolin-stimulated adenylyl cyclase activity | Mus musculus | |
delta opioid receptor agonist DT II | i.e.(d-Ala2)-deltorphin II, delta opioid receptor agonist, 0.001 mM significantly represses forskolin-stimulated adenylyl cyclase activity | Mus musculus | |
opioid receptor agonist DAMGO | i.e. (d-Ala2,N-MePhe4,Gly5-ol)enkephalin, micro opioid receptor agonist, 0.001 mM significantly represses forskolin-stimulated adenylyl cyclase activity | Mus musculus | |
U50488H | kappa opioid receptor agonist | Mus musculus | |
U69593 | kappa opioid receptor agonist | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6J strain | - |
Mus musculus C57/BL6J | - |
C57BL/6J strain | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | striatum | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cAMP + diphosphate | - |
? | |
ATP | - |
Mus musculus C57/BL6J | 3',5'-cAMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC5 | - |
Mus musculus |
adenylyl cyclase type 5 | - |
Mus musculus |