Activating Compound | Comment | Organism | Structure |
---|---|---|---|
BIM-1 | specific protein-kinase C inhibitor, significantly increases cumulus cell cAMP concentrations | Bos taurus | |
clonidine | slight stimulatory effect on cAMP concentrations | Bos taurus | |
EGTA | significantly increases cumulus cell cAMP concentrations | Bos taurus | |
forskolin | increases substantially cAMP concentrations | Bos taurus | |
H89 | specific inhibitor of protein-kinase A, significantly increases cumulus cell cAMP concentrations at 0.0001 and 0.03 mM | Bos taurus | |
ionomycin | increases intracellular Ca2+ concentrations, significantly increases cumulus cell cAMP concentrations | Bos taurus | |
additional information | cholera toxin, KN-62, phorbol-12-myristate-13-acetate and BAPTA-am or a combination of 3 mM EGTA plus BAPTA-am have no effect on cAMP concentrations | Bos taurus | |
pertussis toxin | catalyses ADP-ribosylation of a cysteine residue on GalphaI, causing the G-protein complex to become uncoupled from the receptor, significantly increases cAMP concentrations | Bos taurus | |
staurosporine | non-specific protein-kinase C inhibitor, significantly increases cumulus cell cAMP concentrations | Bos taurus | |
thapsigargin | increases intracellular Ca2+ concentrations, significantly increases cumulus cell cAMP concentrations | Bos taurus |
Application | Comment | Organism |
---|---|---|
medicine | cumulus cells possess multiple active isoforms of adenylyl cyclase, each isoform may have a specific role at a specific time during oocyte growth and maturation | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Bos taurus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | all nine membrane-associated isoforms | Bos taurus | - |
granulosa cell | AC isoforms 3, 4, 6, 8, and 9 | Bos taurus | - |
additional information | AC isoforms 1, 3, 4, 6, and 9 in cumulus cells. AC1, AC4 and AC6 predominate | Bos taurus | - |
ovary | - |
Bos taurus | - |
testis | sAC | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Bos taurus | 3',5'-cAMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC1 | - |
Bos taurus |
AC2 | - |
Bos taurus |
AC3 | - |
Bos taurus |
AC4 | - |
Bos taurus |
AC5 | - |
Bos taurus |
AC6 | - |
Bos taurus |
AC7 | - |
Bos taurus |
AC8 | - |
Bos taurus |
AC9 | - |
Bos taurus |
adenylate cyclases I | - |
Bos taurus |
adenylate cyclases IV | - |
Bos taurus |
adenylate cyclases VI | - |
Bos taurus |
sAC | - |
Bos taurus |
soluble adenylyl cyclase | - |
Bos taurus |