Literature summary for 4.4.1.41 extracted from

Liu, J.; Wei, Y.; Lin, L.; Teng, L.; Yin, J.; Lu, Q.; Chen, J.; Zheng, Y.; Li, Y.; Xu, R.; Zhai, W.; Liu, Y.; Liu, Y.; Cao, P.; Ang, E.; Zhao, H.; Yuchi, Z.; Zhang, Y.
Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate (2020), Proc. Natl. Acad. Sci. USA, 117, 15599 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
structure in complex with (2S)-2,3-dihydroxypropane-1-sulfonate, to 2.2 A resolution. The space group C121 crystals contain four monomers per asymmetric unit	Bilophila wadsworthia

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
13	-	(2S)-2,3-dihydroxypropane-1-sulfonate	pH 7.5, 23°C	Bilophila wadsworthia

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(2S)-2,3-dihydroxypropane-1-sulfonate	Bilophila wadsworthia	-	hydroxyacetone + sulfite	-	?
(2S)-2,3-dihydroxypropane-1-sulfonate	Bilophila wadsworthia 3_1_6	-	hydroxyacetone + sulfite	-	?

Organism

Organism	UniProt	Comment	Textmining
Bilophila wadsworthia	E5Y7I4	-	-
Bilophila wadsworthia 3_1_6	E5Y7I4	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2S)-2,3-dihydroxypropane-1-sulfonate	-	Bilophila wadsworthia	hydroxyacetone + sulfite	-	?
(2S)-2,3-dihydroxypropane-1-sulfonate	-	Bilophila wadsworthia 3_1_6	hydroxyacetone + sulfite	-	?
additional information	enzyme additionally catalyzes isethionate desulfonation, reaction of EC 4.4.1.38, albeit with much lower activity	Bilophila wadsworthia	?	-	-
additional information	enzyme additionally catalyzes isethionate desulfonation, reaction of EC 4.4.1.38, albeit with much lower activity	Bilophila wadsworthia 3_1_6	?	-	-

Synonyms

Synonyms	Comment	Organism
DHPS-sulfolyase	-	Bilophila wadsworthia
HMPREF0179_02149	-	Bilophila wadsworthia
hpsG	-	Bilophila wadsworthia

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
26	-	(2S)-2,3-dihydroxypropane-1-sulfonate	pH 7.5, 23°C	Bilophila wadsworthia

General Information

General Information	Comment	Organism
physiological function	DHPS-sulfolyase HpsG in sulfate- and sulfite-reducing bacteria catalyzes C-S cleavage to release sulfite for use as a terminal electron acceptor in respiration, producing H2S. HpsG is a glycerol dehydratase family glycyl radical enzyme and can be activated by anaerobically reconstituted HpsH	Bilophila wadsworthia

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
1.9	-	(2S)-2,3-dihydroxypropane-1-sulfonate	pH 7.5, 23°C	Bilophila wadsworthia

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Release 2023.1 (January 2023)