Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
polysome | - |
Rattus norvegicus | 5844 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
native enzyme, SDS-PAGE | Homo sapiens |
35000 | - |
native enzyme, SDS-PAGE | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
heparin-Sepharose column chromatography and Superdex 75 gel filtration | Rattus norvegicus |
Ni-NTA column chromatography and Superdex 75 gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
c-myc coding region determinant mRNA | APE1 preferentially cleaves in between UA and CA dinucleotides of c-myc coding region determinant RNA | Homo sapiens | ? | - |
? | |
c-myc coding region determinant mRNA | APE1 preferentially cleaves in between UA and CA dinucleotides of c-myc coding region determinant RNA | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AP DNA endonuclease 1 | - |
Homo sapiens |
AP DNA endonuclease 1 | - |
Rattus norvegicus |
APE1 | - |
Homo sapiens |
APE1 | - |
Rattus norvegicus |
apurinic/apyrimidinic DNA endonuclease 1 | - |
Homo sapiens |
apurinic/apyrimidinic DNA endonuclease 1 | - |
Rattus norvegicus |
Ref-1 | - |
Homo sapiens |
Ref-1 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | APE1 regulates c-myc mRNA level possibly via its endoribonuclease activity | Homo sapiens |
physiological function | APE1 regulates c-myc mRNA level possibly via its endoribonuclease activity | Rattus norvegicus |