Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.99.18 extracted from

  • Lee, H.M.; Yuk, J.M.; Shin, D.M.; Yang, C.S.; Kim, K.K.; Choi, D.K.; Liang, Z.L.; Kim, J.M.; Jeon, B.H.; Kim, C.D.; Lee, J.H.; Jo, E.K.
    Apurinic/apyrimidinic endonuclease 1 is a key modulator of keratinocyte inflammatory responses (2009), J. Immunol., 183, 6839-6848.
    View publication on PubMed
Search for more literature for 4.2.99.18

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HaCaT cell
-
 Homo sapiens
-
keratinocyte
-
 Homo sapiens
-
skin nuclear expression of APE1 in epidermal layers is markedly up-regulated in psoriatic skin, APE1 is essential for the transcriptional activation and nuclear translocation of hypoxia-inducible factor-1alpha and NF-kappaB Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
 Homo sapiens fragments of DNA
-
 ?

Synonyms

Synonyms Comment Organism
APE1
-
 Homo sapiens
apurinic-apyrimidinic endonuclease 1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens APE1 expression is up-regulated in psoriatic epidermis up

General Information

General Information Comment Organism
physiological function APE1 is a key upstream regulator in TLR2-dependent keratinocyte inflammatory responses Homo sapiens