Literature summary for 4.2.3.190 extracted from

Pateraki, I.; Andersen-Ranberg, J.; Hamberger, B.; Heskes, A.M.; Martens, H.J.; Zerbe, P.; Bach, S.S.; Moller, B.L.; Bohlmann, J.; Hamberger, B.
Manoyl oxide (13R), the biosynthetic precursor of forskolin, is synthesized in specialized root cork cells in Coleus forskohlii (2014), Plant Physiol., 164, 1222-1236 .

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Organism

Organism	UniProt	Comment	Textmining
Plectranthus barbatus	X5A2Z7	-	-
Plectranthus barbatus	X5AHD9	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	expression across all tissues	Plectranthus barbatus	-
additional information	transcripts are mostly detected in the aerial parts of the plant, especially in the leaves. Transcript level is relatively low across all tissues	Plectranthus barbatus	-
root	low transcript level	Plectranthus barbatus	-
root	root cork cell, high transcript level	Plectranthus barbatus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate	-	Plectranthus barbatus	manoyl oxide + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
TPS3	-	Plectranthus barbatus
TPS4	-	Plectranthus barbatus

General Information

General Information	Comment	Organism
physiological function	TPS2, which synthesizes the intermediate copal-8-ol diphosphate, in combination with TPS3 leads to the stereospecific formation of (13R) manoyl oxide. In extracts from Nicotiana benthamiana coexpressing TPS2 with TPS3, only the (13R) epimer of manoyl oxide is identified, while the combination of TPS1 and TPS3 leads to formation of miltiradiene	Plectranthus barbatus
physiological function	TPS2, which synthesizes the intermediate copal-8-ol diphosphate, in combination with TPS4 leads to the stereospecific formation of (13R) manoyl oxide. In extracts from Nicotiana benthamiana coexpressing TPS2 with TPS4, only the (13R) epimer of manoyl oxide is identified, while the combination of TPS1 and TPS4 leads to formation of miltiradiene	Plectranthus barbatus

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Release 2023.1 (January 2023)