Crystallization (Comment) | Organism |
---|---|
analysis of structure PDB ID 1IRE | Pseudonocardia thermophila |
analysis of structure PDB ID 2QDY | Rhodococcus erythropolis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | Co-type NHase | Pseudonocardia thermophila | |
Fe2+ | Fe-type NHase | Rhodococcus erythropolis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rhodococcus erythropolis | molecular modeling study of enzyme-substrate binding modes in the bi-enzyme pathway for degradation of nitrile to acid, specific residues within the enzyme's binding pockets form diverse contacts with the substrate, molecular docking, overview. Top substrate having favorable interactions with nitrile hydratase is benzonitrile | ? | - |
? | |
additional information | Pseudonocardia thermophila | molecular modeling study of enzyme-substrate binding modes in the bi-enzyme pathway for degradation of nitrile to acid, specific residues within the enzyme's binding pockets formed diverse contacts with the substrate, molecular docking, overview. Top substrate having favorable interactions with nitrile hydratase is 3-cyanopyridine | ? | - |
? | |
additional information | Pseudonocardia thermophila JCM 3095 | molecular modeling study of enzyme-substrate binding modes in the bi-enzyme pathway for degradation of nitrile to acid, specific residues within the enzyme's binding pockets formed diverse contacts with the substrate, molecular docking, overview. Top substrate having favorable interactions with nitrile hydratase is 3-cyanopyridine | ? | - |
? | |
additional information | Rhodococcus erythropolis AJ270 | molecular modeling study of enzyme-substrate binding modes in the bi-enzyme pathway for degradation of nitrile to acid, specific residues within the enzyme's binding pockets form diverse contacts with the substrate, molecular docking, overview. Top substrate having favorable interactions with nitrile hydratase is benzonitrile | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudonocardia thermophila | Q7SID2 | alpha-subunit | - |
Pseudonocardia thermophila JCM 3095 | Q7SID2 | alpha-subunit | - |
Rhodococcus erythropolis | P13448 | - |
- |
Rhodococcus erythropolis AJ270 | P13448 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,2-dimethylcyclopropanecarbonitrile + H2O | - |
Rhodococcus erythropolis | ? | - |
? | |
2-hydroxy-4-phenylbutanenitrile + H2O | - |
Rhodococcus erythropolis | ? | - |
? | |
3-cyanopyridine + H2O | - |
Pseudonocardia thermophila | pyridine-3-carbamide | - |
? | |
3-cyanopyridine + H2O | - |
Rhodococcus erythropolis | pyridine-3-carbamide | - |
? | |
3-cyanopyridine + H2O | - |
Pseudonocardia thermophila JCM 3095 | pyridine-3-carbamide | - |
? | |
3-cyanopyridine + H2O | - |
Rhodococcus erythropolis AJ270 | pyridine-3-carbamide | - |
? | |
4-chloro-3-hydroxybutanenitrile + H2O | - |
Rhodococcus erythropolis | ? | - |
? | |
acetonitrile + H2O | - |
Rhodococcus erythropolis | acetamide | - |
? | |
acetonitrile + H2O | - |
Rhodococcus erythropolis AJ270 | acetamide | - |
? | |
acrylonitrile + H2O | - |
Pseudonocardia thermophila | ? | - |
? | |
acrylonitrile + H2O | - |
Pseudonocardia thermophila JCM 3095 | ? | - |
? | |
acrylonitrile + H2O | - |
Rhodococcus erythropolis | acrylamide | - |
? | |
acrylonitrile + H2O | - |
Rhodococcus erythropolis AJ270 | acrylamide | - |
? | |
benzonitrile + H2O | - |
Pseudonocardia thermophila | ? | - |
? | |
benzonitrile + H2O | - |
Pseudonocardia thermophila JCM 3095 | ? | - |
? | |
benzonitrile + H2O | - |
Rhodococcus erythropolis | benzamide | - |
? | |
butyronitrile + H2O | - |
Rhodococcus erythropolis | ? | - |
? | |
isobutyronitrile + H2O | - |
Rhodococcus erythropolis | ? | - |
? | |
methacrylonitrile + H2O | - |
Pseudonocardia thermophila | ? | - |
? | |
methacrylonitrile + H2O | - |
Rhodococcus erythropolis | methacrylamide | - |
? | |
additional information | substrate specificity, overview | Pseudonocardia thermophila | ? | - |
? | |
additional information | substrate specificity, overview | Rhodococcus erythropolis | ? | - |
? | |
additional information | molecular modeling study of enzyme-substrate binding modes in the bi-enzyme pathway for degradation of nitrile to acid, specific residues within the enzyme's binding pockets form diverse contacts with the substrate, molecular docking, overview. Top substrate having favorable interactions with nitrile hydratase is benzonitrile | Rhodococcus erythropolis | ? | - |
? | |
additional information | molecular modeling study of enzyme-substrate binding modes in the bi-enzyme pathway for degradation of nitrile to acid, specific residues within the enzyme's binding pockets formed diverse contacts with the substrate, molecular docking, overview. Top substrate having favorable interactions with nitrile hydratase is 3-cyanopyridine | Pseudonocardia thermophila | ? | - |
? | |
additional information | substrate specificity, overview | Pseudonocardia thermophila JCM 3095 | ? | - |
? | |
additional information | molecular modeling study of enzyme-substrate binding modes in the bi-enzyme pathway for degradation of nitrile to acid, specific residues within the enzyme's binding pockets formed diverse contacts with the substrate, molecular docking, overview. Top substrate having favorable interactions with nitrile hydratase is 3-cyanopyridine | Pseudonocardia thermophila JCM 3095 | ? | - |
? | |
additional information | substrate specificity, overview | Rhodococcus erythropolis AJ270 | ? | - |
? | |
additional information | molecular modeling study of enzyme-substrate binding modes in the bi-enzyme pathway for degradation of nitrile to acid, specific residues within the enzyme's binding pockets form diverse contacts with the substrate, molecular docking, overview. Top substrate having favorable interactions with nitrile hydratase is benzonitrile | Rhodococcus erythropolis AJ270 | ? | - |
? | |
propionitrile + H2O | - |
Rhodococcus erythropolis | propionamide | - |
? | |
tert-butylisonitrile + H2O | - |
Pseudonocardia thermophila | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NHase | - |
Pseudonocardia thermophila |
NHase | - |
Rhodococcus erythropolis |
General Information | Comment | Organism |
---|---|---|
metabolism | hydrolysis mediated by nitrilase, NHase, and amidase is the most common way for nitrile degradation | Pseudonocardia thermophila |
metabolism | hydrolysis mediated by nitrilase, NHase, and amidase is the most common way for nitrile degradation | Rhodococcus erythropolis |