Cloned (Comment) | Organism |
---|---|
semi-quantitative real-time PCR analysis of ubiquitous and erythroid-specific UROS mRNAs, expression analysis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hydroxymethylbilane | Homo sapiens | intramolecular rearrangement of the d-pyrrole group and ring closure | uroporphyrinogen III + H2O | - |
? | |
additional information | Homo sapiens | hydroxymethylbilane synthase and uroporphyrinogen III synthase catalyze two consecutive reactions, the third and fourth step, in the heme biosynthetic pathway, generating the first linear and the first cyclic tetrapyrroles, respectively. Hydroxymethylbilane synthase, 2.5.1.61, and uroporphyrinogen III synthase may function independently and sequentially with hydroxymethylbilane as a free intermediate, heme biosynthetic pathway, overview. Hypoxia downregulates UROS mRNA expression in hepatic cells, reduction of UROS mRNA is associated with the accumulation of hypoxia-inducible factor 1alpha under normoxia. Deferoxamine, cobalt chloride, or hypoxia downregulate UROS mRNA expression in hepatic cells, reduction of UROS mRNA is associated with the accumulation of hypoxia-inducible factor 1alpha under normoxia | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEP-3B cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
K-562 cell | erythroleukemia cells | Homo sapiens | - |
liver | - |
Homo sapiens | - |
YN-1 cell | erythroleukemia cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hydroxymethylbilane | intramolecular rearrangement of the d-pyrrole group and ring closure | Homo sapiens | uroporphyrinogen III + H2O | - |
? | |
additional information | hydroxymethylbilane synthase and uroporphyrinogen III synthase catalyze two consecutive reactions, the third and fourth step, in the heme biosynthetic pathway, generating the first linear and the first cyclic tetrapyrroles, respectively. Hydroxymethylbilane synthase, 2.5.1.61, and uroporphyrinogen III synthase may function independently and sequentially with hydroxymethylbilane as a free intermediate, heme biosynthetic pathway, overview. Hypoxia downregulates UROS mRNA expression in hepatic cells, reduction of UROS mRNA is associated with the accumulation of hypoxia-inducible factor 1alpha under normoxia. Deferoxamine, cobalt chloride, or hypoxia downregulate UROS mRNA expression in hepatic cells, reduction of UROS mRNA is associated with the accumulation of hypoxia-inducible factor 1alpha under normoxia | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hydroxymethylbilane hydrolyase, cyclizing | - |
Homo sapiens |
Uroporphyrinogen III synthase | - |
Homo sapiens |
UROS | - |
Homo sapiens |