Activating Compound | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | about 4fold increase of specific activity in the presence of 0.25 mM S-adenosyl-L-methionine | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
wild type enzyme is expressed in Mus musculus and mutant enzyme S466L is expressed in Saccharomyces cerevisiae strain WY35 and in Mus musculus | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S466L | the mutation causes hyperhomocysteinemia by affecting both the steady state level of CBS protein and by reducing the efficiency of the enzyme in vivo, S466L is enzymatically active, forms tetramers, and lacks S-adenosyl-L-methionine inducibility | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.77 | - |
L-serine | mutant enzyme S466L, in the presence of 0.25 mM S-adenosyl-L-methionine | Homo sapiens | |
0.78 | - |
L-serine | wild type enzyme, in the presence of 0.25 mM S-adenosyl-L-methionine | Homo sapiens | |
1.1 | - |
L-homocysteine | mutant enzyme S466L, in the presence of 0.25 mM S-adenosyl-L-methionine | Homo sapiens | |
2.5 | - |
L-homocysteine | wild type enzyme, in the presence of 0.25 mM S-adenosyl-L-methionine | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | highest activity | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-serine + L-homocysteine | - |
Homo sapiens | L-cystathionine + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CBS | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |