Literature summary for 4.2.1.20 extracted from

Wu, Y.; Vadrevu, R.; Kathuria, S.; Yang, X.; Matthews, C.R.
A tightly packed hydrophobic cluster directs the formation of an off-pathway sub-millisecond folding intermediate in the alpha subunit of tryptophan synthase, a TIM barrel protein (2007), J. Mol. Biol., 366, 1624-1638.

Search for more literature for 4.2.1.20

Cloned(Commentary)

Cloned (Comment)	Organism
-	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
I37A	mutant lacks the hundreds of milliseconds unfolding reaction under strongly refolding conditions	Escherichia coli
I41A	mutant lacks the hundreds of milliseconds unfolding reaction under strongly refolding conditions	Escherichia coli
I95A	mutant lacks the hundreds of milliseconds unfolding reaction under strongly refolding conditions	Escherichia coli
I97A	mutant lacks the hundreds of milliseconds unfolding reaction under strongly refolding conditions	Escherichia coli
L25A	mutant lacks the hundreds of milliseconds unfolding reaction under strongly refolding conditions	Escherichia coli
L48A	mutant lacks the hundreds of milliseconds unfolding reaction under strongly refolding conditions	Escherichia coli
L50A	mutant lacks the hundreds of milliseconds unfolding reaction under strongly refolding conditions	Escherichia coli
L85A	mutant lacks the hundreds of milliseconds unfolding reaction under strongly refolding conditions	Escherichia coli
L99A	mutant lacks the hundreds of milliseconds unfolding reaction under strongly refolding conditions	Escherichia coli
V23A	mutant lacks the hundreds of milliseconds unfolding reaction under strongly refolding conditions	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0A877	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-serine + indole	-	Escherichia coli	L-tryptophan + H2O	-	?

Synonyms

Synonyms	Comment	Organism
alphaTS	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Escherichia coli

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Release 2023.1 (January 2023)