Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-(N,N-dimethylamino)cinnamoyl-CoA + H2O | Homo sapiens | - |
? | - |
? | |
crotonyl-CoA + H2O | Homo sapiens | - |
3-hydroxybutyryl-CoA | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P30084 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O | reaction mechansim of enoyl-CoA hydration, overview | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-(N,N-dimethylamino)cinnamoyl-CoA + H2O | - |
Homo sapiens | ? | - |
? | |
4-(N,N-dimethylamino)cinnamoyl-CoA + H2O | - |
Homo sapiens | ? | - |
r | |
crotonyl-CoA + H2O | - |
Homo sapiens | 3-hydroxybutyryl-CoA | - |
r | |
crotonyl-CoA + H2O | preferred substrate | Homo sapiens | 3-hydroxybutyryl-CoA | - |
r |
Synonyms | Comment | Organism |
---|---|---|
ECH | - |
Homo sapiens |
enoyl-CoA hydratase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | molecular mechanism analysis by density functional theory methods, overview. Residue Glu164 functions as the acid/base in catalysis. And although Glu144 is not directly involved in hydration, it induces the catalytic water molecule to locate in ideal orientation to attack the double bond of substrate by hydrogen-bonding interaction. The backbone NH groups of Ala98 and Gly141 form an oxyanion whole with substrate carbonyl oxygen, playing a key role in substrate binding and stabilization of generated transition states and intermediates | Homo sapiens |
physiological function | the enzyme is the second requisite enzyme in the beta-oxidation pathway of fatty acids that catalyzes the syn hydration of alpha,beta-unsaturated thiolester substrates | Homo sapiens |