Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.2.1.130 extracted from

  • Natkanska, U.; Skoneczna, A.; Sienko, M.; Skoneczny, M.
    The budding yeast orthologue of Parkinsons disease-associated DJ-1 is a multi-stress response protein protecting cells against toxic glycolytic products (2017), Biochim. Biophys. Acta, 1864, 39-50 .
No PubMed abstract available
Search for more literature for 4.2.1.130

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae Q04432
-
-
Saccharomyces cerevisiae ATCC 204508 Q04432
-
-

Synonyms

Synonyms Comment Organism
glutathione-independent glyoxalase
-
 Saccharomyces cerevisiae
Hsp31
-
 Saccharomyces cerevisiae
Hsp31p glyoxalase III
-
 Saccharomyces cerevisiae

Expression

Organism Comment Expression
Saccharomyces cerevisiae strong induction of this gene is caused by high concentrations of ethanol and other products of glycolysis. HSP31 gene expression is controlled by multiple transcription factors, including Yap1p, Cad1p, Msn2p, Msn4p, Haa1p and Hsf1p. These transcription factors mediate the HSP31 promoter responses to oxidative, osmotic and thermal stresses, to potentially toxic products of glycolysis, such as methylglyoxal and acetic acid, and to the diauxic shift up

General Information

General Information Comment Organism
malfunction the absence of the HSP31 gene sensitizes cells to oxidative, osmotic and thermal stresses, to potentially toxic products of glycolysis, such as methylglyoxal and acetic acid, and to the diauxic shift Saccharomyces cerevisiae
physiological function the enzyme is important for survival in the stationary phase of growth and under oxidative stress. It eliminates various toxic products of glycolysis Saccharomyces cerevisiae