Literature summary for 4.2.1.1 extracted from

Zimmerman, S.; Innocenti, A.; Casini, A.; Ferry, J.G.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides (2004), Bioorg. Med. Chem. Lett., 14, 6001-6006.

Inhibitors

Inhibitors	Comment	Organism
1,5-bis[amino(dihydroxy)-lambda4-sulfanyl]-2,3-dichlorobenzene	-	Methanosarcina thermophila
1,5-bis[amino(dihydroxy)-lambda4-sulfanyl]-2,3-dichlorobenzene	-	Methanothermobacter thermautotrophicus
1-[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]ethanamine	-	Methanosarcina thermophila
1-[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]ethanamine	-	Methanothermobacter thermautotrophicus
1-[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]methanamine	-	Methanosarcina thermophila
1-[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]methanamine	-	Methanothermobacter thermautotrophicus
2,4-bis[amino(dihydroxy)-lamba4-sulfanyl]-5-(trifluoromethyl)aniline	-	Methanosarcina thermophila
2,4-bis[amino(dihydroxy)-lamba4-sulfanyl]-5-(trifluoromethyl)aniline	-	Methanothermobacter thermautotrophicus
2,4-bis[amino(dihydroxy)-lambda4-sulfanyl]-5-chloroaniline	-	Methanosarcina thermophila
2,4-bis[amino(dihydroxy)-lambda4-sulfanyl]-5-chloroaniline	-	Methanothermobacter thermautotrophicus
3-[amino(dihydroxy)-lambda4-sulfanyl]aniline	-	Methanosarcina thermophila
3-[amino(dihydroxy)-lambda4-sulfanyl]aniline	-	Methanothermobacter thermautotrophicus
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide	-	Methanosarcina thermophila
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide	-	Methanothermobacter thermautotrophicus
4-[amino(dihydroxy)-lambda4-sulfanyl]-2-bromoaniline	-	Methanosarcina thermophila
4-[amino(dihydroxy)-lambda4-sulfanyl]-2-bromoaniline	-	Methanothermobacter thermautotrophicus
4-[amino(dihydroxy)-lambda4-sulfanyl]-2-chloroaniline	-	Methanosarcina thermophila
4-[amino(dihydroxy)-lambda4-sulfanyl]-2-chloroaniline	-	Methanothermobacter thermautotrophicus
4-[amino(dihydroxy)-lambda4-sulfanyl]-2-fluoroaniline	-	Methanosarcina thermophila
4-[amino(dihydroxy)-lambda4-sulfanyl]-2-fluoroaniline	-	Methanothermobacter thermautotrophicus
4-[amino(dihydroxy)-lambda4-sulfanyl]-2-iodoaniline	-	Methanosarcina thermophila
4-[amino(dihydroxy)-lambda4-sulfanyl]-2-iodoaniline	-	Methanothermobacter thermautotrophicus
acetazolamide	-	Methanosarcina thermophila
acetazolamide	-	Methanothermobacter thermautotrophicus
celecoxib	-	Methanosarcina thermophila
celecoxib	-	Methanothermobacter thermautotrophicus
dorzolamide	-	Methanosarcina thermophila
dorzolamide	-	Methanothermobacter thermautotrophicus
ethoxzolamide	-	Methanosarcina thermophila
ethoxzolamide	-	Methanothermobacter thermautotrophicus
methazolamide	-	Methanosarcina thermophila
methazolamide	-	Methanothermobacter thermautotrophicus
sulfamic acid	-	Methanosarcina thermophila
sulfamic acid	-	Methanothermobacter thermautotrophicus
sulfamide	-	Methanosarcina thermophila
sulfamide	-	Methanothermobacter thermautotrophicus
sulfanilamide	-	Methanosarcina thermophila
sulfanilamide	-	Methanothermobacter thermautotrophicus
topiramate	-	Methanosarcina thermophila
topiramate	-	Methanothermobacter thermautotrophicus
valdecoxib	-	Methanosarcina thermophila
valdecoxib	-	Methanothermobacter thermautotrophicus
[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]hydrazine	-	Methanosarcina thermophila
[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]hydrazine	-	Methanothermobacter thermautotrophicus

Organism

Organism	UniProt	Comment	Textmining
Methanosarcina thermophila	P40881	-	-
Methanothermobacter thermautotrophicus	-	-	-

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
20	-	assay at	Methanothermobacter thermautotrophicus
20	-	assay at	Methanosarcina thermophila

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
0.000063	-	acetazolamide	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.000096	-	sulfamic acid	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00012	-	topiramate	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00012	-	2,4-bis[amino(dihydroxy)-lambda4-sulfanyl]-5-chloroaniline	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00013	-	valdecoxib	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00014	-	methazolamide	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00014	-	celecoxib	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00014	-	4-[amino(dihydroxy)-lambda4-sulfanyl]-2-chloroaniline	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00015	-	1,5-bis[amino(dihydroxy)-lambda4-sulfanyl]-2,3-dichlorobenzene	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00017	-	methazolamide	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00017	-	3-[amino(dihydroxy)-lambda4-sulfanyl]aniline	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00018	-	4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00019	-	1,5-bis[amino(dihydroxy)-lambda4-sulfanyl]-2,3-dichlorobenzene	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.0002	-	ethoxzolamide	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00022	-	[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]hydrazine	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00024	-	valdecoxib	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00025	-	sulfanilamide	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00027	-	1-[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]ethanamine	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00028	-	4-[amino(dihydroxy)-lambda4-sulfanyl]-2-bromoaniline	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00028	-	4-[amino(dihydroxy)-lambda4-sulfanyl]-2-iodoaniline	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00035	-	1-[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]methanamine	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00041	-	dorzolamide	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00061	-	2,4-bis[amino(dihydroxy)-lambda4-sulfanyl]-5-chloroaniline	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00066	-	4-[amino(dihydroxy)-lambda4-sulfanyl]-2-iodoaniline	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00074	-	ethoxzolamide	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00074	-	4-[amino(dihydroxy)-lambda4-sulfanyl]-2-chloroaniline	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00083	-	2,4-bis[amino(dihydroxy)-lamba4-sulfanyl]-5-(trifluoromethyl)aniline	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00095	-	2,4-bis[amino(dihydroxy)-lamba4-sulfanyl]-5-(trifluoromethyl)aniline	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00097	-	4-[amino(dihydroxy)-lambda4-sulfanyl]-2-fluoroaniline	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00101	-	celecoxib	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00102	-	topiramate	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00124	-	3-[amino(dihydroxy)-lambda4-sulfanyl]aniline	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.0013	-	1-[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]ethanamine	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00143	-	acetazolamide	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00171	-	dorzolamide	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00172	-	4-[amino(dihydroxy)-lambda4-sulfanyl]-2-bromoaniline	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.0022	-	[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]hydrazine	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.00336	-	sulfamic acid	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00393	-	sulfanilamide	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.0042	-	4-[amino(dihydroxy)-lambda4-sulfanyl]-2-fluoroaniline	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00535	-	ethoxzolamide	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.00596	-	sulfamide	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.00636	-	4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.0085	-	1-[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]methanamine	20°C, pH not specified in the publication, Co2+-containing enzyme	Methanosarcina thermophila
0.012	-	acetazolamide	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.0143	-	3-[amino(dihydroxy)-lambda4-sulfanyl]aniline	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.0235	-	topiramate	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.0257	-	1-[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]ethanamine	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.0285	-	1-[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]methanamine	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.0307	-	dorzolamide	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.032	-	methazolamide	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.0385	-	celecoxib	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.05	-	2,4-bis[amino(dihydroxy)-lamba4-sulfanyl]-5-(trifluoromethyl)aniline	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.0524	-	4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.0534	-	4-[amino(dihydroxy)-lambda4-sulfanyl]-2-fluoroaniline	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.0578	-	sulfanilamide	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.061	-	valdecoxib	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.0621	-	2,4-bis[amino(dihydroxy)-lambda4-sulfanyl]-5-chloroaniline	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.069	-	sulfamide	20°C, pH not specified in the publication, Zn2+-containing enzyme	Methanosarcina thermophila
0.077	-	4-[amino(dihydroxy)-lambda4-sulfanyl]-2-bromoaniline	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.098	-	4-[amino(dihydroxy)-lambda4-sulfanyl]-2-iodoaniline	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.105	-	1,5-bis[amino(dihydroxy)-lambda4-sulfanyl]-2,3-dichlorobenzene	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.111	-	4-[amino(dihydroxy)-lambda4-sulfanyl]-2-chloroaniline	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
0.127	-	[4-[amino(dihydroxy)-lambda4-sulfanyl]phenyl]hydrazine	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
44	-	sulfamide	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus
103	-	sulfamic acid	20°C, pH not specified in the publication	Methanothermobacter thermautotrophicus