Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | CAIX is the only membrane-associated carbonic anhydrase inMDA-MB-231 cells. EGF induces CAIX translocation to lipid rafts | Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a zinc metalloenzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme CAIX | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | CAIX exists predominantly as a dimeric, high-mannose N-linked glycoprotein | Homo sapiens |
phosphoprotein | CAIX tyrosine phosphorylation in the cytoplasmic domain. EGF induces CAIX translocation to lipid rafts but not its phosphorylation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MDA-MB-231 cell | CAIX is localized in lipid rafts | Homo sapiens | - |
additional information | CAIX is overexpressed in many types of cancer, including breast cancer, but is most frequently absent in corresponding normal tissues | Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 54000-58000, SDS-PAGE | Homo sapiens |
More | the active form of CAIX in the MDA-MB-231 breast cancer cell line is dimeric but that neither lipid raft localization nor phosphorylation are likely required for its dimerization or activity | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CAIX | - |
Homo sapiens |
carbonic anhydrase IX | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | CAIX expression is 5-7fold induced by hypoxia and is significantly associated with tumor grade and poor survival, overview | up |
General Information | Comment | Organism |
---|---|---|
additional information | EGF induces CAIX translocation to lipid rafts but not its phosphorylation | Homo sapiens |
physiological function | CAIX is a zinc metalloenzyme that catalyzes the reversible hydration of CO2. CAIX expression is strongly induced by hypoxia and is significantly associated with tumor grade and poor survival | Homo sapiens |