Cloned (Comment) | Organism |
---|---|
ICL loss-of-function mutant strain DELTAicl complemented with the functional ICL gene using the integrative vector pMV306 | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WKK7 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WKK7 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
ICL | - |
Mycobacterium tuberculosis |
isocitrate lyase | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
malfunction | nutrient-starved bacilli lacking the glyoxylate shunt enzyme isocitrate lyase fail to reduce their intracellular ATP level and die, thus establishing a link between ATP control and intermediary metabolism. ICL loss-of-function mutant dies in the Loebel model. Viability is fully restored when the mutant strain is complemented with a wild-type copy of ICL | Mycobacterium tuberculosis |
physiological function | ICL gene is required for non-growing survival in the Loebel model (nutrient deprivation in oxygen-rich medium) | Mycobacterium tuberculosis |