Literature summary for 4.1.2.47 extracted from

Zhao, Y.; Chen, N.; Mo, Y.; Cao, Z.
A full picture of enzymatic catalysis by hydroxynitrile lyases from Hevea brasiliensis Protonation dependent reaction steps and residue-gated movement of the substrate and the product (2014), Phys. Chem. Chem. Phys., 16, 26864-26875 .

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Organism

Organism	UniProt	Comment	Textmining
Hevea brasiliensis	P52704	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	on the basis of extensive QM/MM MD and RAMD MD simulations, the catalytic mechanism of the enzyme and its substrate delivery and product (HCN) release are explored. The catalytic reaction approximately follows a two-stage mechanism. The first stage involves two fast processes including the proton abstraction of the substrate through a double-proton transfer and the C-CN bond cleavage, while the second stage concerns HCN formation and is rate-determining	Hevea brasiliensis	?	-	?

General Information

General Information	Comment	Organism
physiological function	hydroxynitrile lyases defend plants from herbivores and microbial attack by releasing cyanide from hydroxynitriles	Hevea brasiliensis

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Release 2023.1 (January 2023)