Application | Comment | Organism |
---|---|---|
medicine | MCD is a potential novel target for cancer treatment | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-[(morpholine-4-carbonyl)-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-phenyl]-amino]-pentanoic acid methyl ester | 30% inhibition at 0.08 mg/ml, 50% inhibition at approximately 0.16 mg/ml | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Malonyl-CoA | - |
Homo sapiens | Acetyl-CoA + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MCD | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | malonyl-CoA is both a substrate for fatty acid synthase and an inhibitor of fatty acid oxidation acting as a metabolic switch between anabolic fatty acid synthesis and catabolic fatty acid oxidation | Homo sapiens |