Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside | AMP-activated protein kinase activator, 2fold activation of MCD in extensor digitorum longus, reversed by protein phosphatase A | Rattus norvegicus | |
additional information | gastrocnemius contraction activates MCD, reversed by protein phosphatase A or by omitting phosphatase inhibitors from assay mixture, increase of MCD activity after skeletal muscle contraction is likely due to its phosphorylation by AMP-activated protein kinase | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.119 | - |
malonyl-CoA | gastrocnemius after 5 min of contraction | Rattus norvegicus | |
0.19 | - |
malonyl-CoA | gastrocnemius, relaxed | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Malonyl-CoA | Rattus norvegicus | control of malonyl-CoA concentration | Acetyl-CoA + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Harlan Sprague-Dawley rats | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | activation of AMP-activated protein kinase during muscle contraction leads to phosphorylation of MCD and an increase in its activity | Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
partial | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Malonyl-CoA | - |
Rattus norvegicus | Acetyl-CoA + CO2 | - |
? | |
Malonyl-CoA | control of malonyl-CoA concentration | Rattus norvegicus | Acetyl-CoA + CO2 | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 8 | - |
Rattus norvegicus |