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Literature summary for 4.1.1.50 extracted from
- Methionine adenosyltransferase (S-adenosylmethionine synthetase) and S-adenosylmethionine decarboxylase (1984), Adv. Enzymol. Relat. Areas Mol. Biol., 56, 251-282.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 1,3-diaminopropane | stimulates | Rattus norvegicus |  |
| 1,3-diaminopropane | stimulates | Saccharomyces cerevisiae | |
| 1,3-diaminopropane | activates | Saccharomyces cerevisiae | |
| cadaverine | activates | Saccharomyces cerevisiae | |
| putrescine | required | Saccharomyces cerevisiae | |
| putrescine | stimulation | Mus musculus | |
| putrescine | stimulation | Homo sapiens | |
| putrescine | stimulation | Rattus norvegicus | |
| putrescine | stimulation | Saccharomyces cerevisiae | |
| putrescine | stimulation | Lytechinus pictus | |
| pyruvate | - |
Homo sapiens | |
| pyruvate | each subunit contains one covalently linked pyruvate | Escherichia coli | |
| pyruvate | each subunit contains one covalently linked pyruvate | Rattus norvegicus | |
| pyruvate | each subunit contains one covalently linked pyruvate | Saccharomyces cerevisiae | |
| spermidine | - |
Saccharomyces cerevisiae | |
| spermidine | - |
Lytechinus pictus | |
| spermidine | weak stimulation | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt | - |
Escherichia coli | |
| (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt | - |
Rattus norvegicus | |
| (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt | - |
Saccharomyces cerevisiae | |
| 1,1'-[(Methylethanediylidene)dinitrilo] bis(3-aminoguanidine) | - |
Rattus norvegicus | |
| Dimethylglyoxal bis(guanylhydrazone) | - |
Rattus norvegicus | |
| ethylglyoxal bis(guanylhydrazone) | - |
Rattus norvegicus | |
| methylglyoxal bis(guanylhydrazone) | competitive | Escherichia coli | |
| methylglyoxal bis(guanylhydrazone) | - |
Homo sapiens | |
| methylglyoxal bis(guanylhydrazone) | - |
Lytechinus pictus | |
| methylglyoxal bis(guanylhydrazone) | - |
Mus musculus | |
| methylglyoxal bis(guanylhydrazone) | reversible | Rattus norvegicus | |
| methylglyoxal bis(guanylhydrazone) | - |
Saccharomyces cerevisiae | |
| NaBH4 | - |
Escherichia coli | |
| NaBH4 | - |
Saccharomyces cerevisiae | |
| NaCNBH3 | inactivation in presence of adenosylmethionine and Mg2+, no inactivation in absence of substrate and Mg2+ | Escherichia coli | |
| NaCNBH3 | - |
Rattus norvegicus | |
| phenylhydrazine | strong | Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Rattus norvegicus | |
| 0.06 | - |
S-adenosylmethionine | - |
Escherichia coli | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | requires a divalent cation, Mg2+, Ca2+ or Mn2+ | Escherichia coli | |
| Mg2+ | requires a divalent cation, Mg2+, Ca2+ or Mn2+ | Escherichia coli | |
| Mn2+ | requires a divalent cation, Mg2+, Ca2+ or Mn2+ | Escherichia coli | |
| Mn2+ | affinity for Mn2+ is increased in presence of substrate | Escherichia coli | |
| additional information | no requirement for a divalent metal ion | Rattus norvegicus | |
| additional information | no requirement for a divalent metal ion | Saccharomyces cerevisiae |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
| 17000 | - |
6 * 17000 | Escherichia coli |
| 41000 | - |
2 * 41000, SDS-PAGE | Saccharomyces cerevisiae |
| 88000 | - |
non-denaturing PAGE | Saccharomyces cerevisiae |
| 108000 | - |
- |
Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine | Mus musculus | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
| S-adenosyl-L-methionine | Escherichia coli | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
| S-adenosyl-L-methionine | Homo sapiens | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
| S-adenosyl-L-methionine | Rattus norvegicus | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
| S-adenosyl-L-methionine | Saccharomyces cerevisiae | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
| S-adenosyl-L-methionine | Bos taurus | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
| S-adenosyl-L-methionine | Lytechinus pictus | key enzyme in the biosynthetic pathway for spermidine and spermine | ? | - |
? | |
| S-adenosyl-L-methionine | Mus musculus | the enzyme protein turns over very rapidly in growing or differentiating tissues | ? | - |
? | |
| S-adenosyl-L-methionine | Homo sapiens | the enzyme protein turns over very rapidly in growing or differentiating tissues | ? | - |
? | |
| S-adenosyl-L-methionine | Rattus norvegicus | the enzyme protein turns over very rapidly in growing or differentiating tissues | ? | - |
? | |
| S-adenosyl-L-methionine | Bos taurus | the enzyme protein turns over very rapidly in growing or differentiating tissues | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Lytechinus pictus | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
- |
Homo sapiens |
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| egg | - |
Lytechinus pictus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| lymphocyte | - |
Bos taurus | - |
| mammary gland | - |
Mus musculus | - |
| muscle | - |
Rattus norvegicus | - |
| prostate gland | - |
Homo sapiens | - |
| prostate gland | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Adenosylethionine | poor substrate | Escherichia coli | ? | - |
? | |
| S-adenosyl-L-methionine | - |
Mus musculus | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Escherichia coli | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Homo sapiens | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Rattus norvegicus | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Saccharomyces cerevisiae | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Bos taurus | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Lytechinus pictus | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Mus musculus | ? | - |
? | |
| S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Escherichia coli | ? | - |
? | |
| S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Homo sapiens | ? | - |
? | |
| S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Rattus norvegicus | ? | - |
? | |
| S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Saccharomyces cerevisiae | ? | - |
? | |
| S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Bos taurus | ? | - |
? | |
| S-adenosyl-L-methionine | key enzyme in the biosynthetic pathway for spermidine and spermine | Lytechinus pictus | ? | - |
? | |
| S-adenosyl-L-methionine | the enzyme protein turns over very rapidly in growing or differentiating tissues | Mus musculus | ? | - |
? | |
| S-adenosyl-L-methionine | the enzyme protein turns over very rapidly in growing or differentiating tissues | Homo sapiens | ? | - |
? | |
| S-adenosyl-L-methionine | the enzyme protein turns over very rapidly in growing or differentiating tissues | Rattus norvegicus | ? | - |
? | |
| S-adenosyl-L-methionine | the enzyme protein turns over very rapidly in growing or differentiating tissues | Bos taurus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Mus musculus |
| dimer | - |
Rattus norvegicus |
| dimer | 2 * 41000, SDS-PAGE | Saccharomyces cerevisiae |
| hexamer | 6 * 17000 | Escherichia coli |
| More | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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