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Literature summary for 4.1.1.33 extracted from
- Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase (2007), Bioorg. Med. Chem. Lett., 17, 6164-6168.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D306A | low activity | Rattus norvegicus |
| D306E | low activity | Rattus norvegicus |
| D306N | low activity | Rattus norvegicus |
| K208A | low activity | Rattus norvegicus |
| K23A | no activity | Rattus norvegicus |
| K27A | low activity | Rattus norvegicus |
| R154A | low activity | Rattus norvegicus |
| R162A | low activity | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-(diphosphenyloxy)-3,4-dimethylpentan-3-ol | - |
Rattus norvegicus |  |
| 1-(diphosphenyloxy)-3-methylpentan-3-ol | - |
Rattus norvegicus | |
| 1-(diphosphenyloxy)-5-fluoro-3-methylpentan-3-ol | - |
Rattus norvegicus | |
| 2,2-difluoromevalonate 5-diphosphate | - |
Rattus norvegicus | |
| 2-fluoromevalonate 5-diphosphate | irreversible inhibitor | Rattus norvegicus | |
| 3-ethyl-2-fluoro-3,5-dihydroxy-pentanate 5-diphosphate | - |
Rattus norvegicus | |
| 4-(diphosphenyloxy)-2-methylbutan-2-ol | - |
Rattus norvegicus | |
| 4-(diphosphenyloxy)-2-phenylbutan-2-ol | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.036 | - |
5-diphosphomevalonate | wild type enzyme | Rattus norvegicus | |
| 0.53 | - |
ATP | wild type enzyme | Rattus norvegicus | |
| 0.75 | - |
5-diphosphomevalonate | mutant enzyme K27A | Rattus norvegicus | |
| 0.92 | - |
5-diphosphomevalonate | mutant enzyme R154A | Rattus norvegicus | |
| 1.4 | - |
ATP | mutant enzyme R154A | Rattus norvegicus | |
| 1.87 | - |
ATP | mutant enzyme K27A | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| nickel metal affinity column chromatography | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 5-diphosphomevalonate | - |
Rattus norvegicus | ADP + phosphate + isopentenyl diphosphate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MDD | - |
Rattus norvegicus |
| mevalonate 5'-diphosphate decarboxylase | - |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0075 | - |
- |
Rattus norvegicus | 2,2-difluoromevalonate 5-diphosphate | |
| 0.02 | - |
- |
Rattus norvegicus | 3-ethyl-2-fluoro-3,5-dihydroxy-pentanate 5-diphosphate | |
| 0.05 | - |
- |
Rattus norvegicus | 1-(diphosphenyloxy)-5-fluoro-3-methylpentan-3-ol | |
| 0.06 | - |
- |
Rattus norvegicus | 4-(diphosphenyloxy)-2-methylbutan-2-ol | |
| 0.08 | - |
- |
Rattus norvegicus | 1-(diphosphenyloxy)-3-methylpentan-3-ol | |
| 0.12 | - |
- |
Rattus norvegicus | 1-(diphosphenyloxy)-3,4-dimethylpentan-3-ol | |
| 0.14 | - |
- |
Rattus norvegicus | 4-(diphosphenyloxy)-2-phenylbutan-2-ol | |
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