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Literature summary for 4.1.1.33 extracted from
- Purification and characterization of avian liver mevalonate-5-pyrophosphate decarboxylase (1982), Biochemistry, 21, 4646-4650.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no requirement for SH-containing reagents for activity | Gallus gallus |
General Stability
| General Stability | Organism |
|---|---|
| no requirement for SH-containing reagents for stability | Gallus gallus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| citrate | inhibits below pH 4.8 | Gallus gallus |  |
| phosphate | - |
Gallus gallus | |
| Phthalate | - |
Gallus gallus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0141 | - |
5-diphosphomevalonate | - |
Gallus gallus | |
| 0.504 | - |
ATP | - |
Gallus gallus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | divalent cation required, Mg2+ is most effective, maximal activity at 1 mM | Gallus gallus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43500 | - |
2 * 43500, SDS-PAGE | Gallus gallus |
| 81500 | - |
sucrose density gradient centrifugation | Gallus gallus |
| 87600 | - |
gel filtration | Gallus gallus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 6.26 | - |
- |
Gallus gallus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, Tris-HCl buffer, pH 7.0, 20% glycerol, 75 mM KCl, stable for 1 month | Gallus gallus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 5-diphosphomevalonate | high specificity for ATP | Gallus gallus | ADP + phosphate + isopentenyl diphosphate + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 43500, SDS-PAGE | Gallus gallus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 6.5 | - |
Gallus gallus |
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