Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-2-amino-3-(3-hydroxyphenyl)-2-methylpropanoic acid | IC50: 6.37 mM | Locusta migratoria | |
(2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid | IC50: 9.4 mM | Locusta migratoria | |
3-hydroxybenzyl-hydrazine | potent inhibitor, IC50: 0.0004 mM | Locusta migratoria | |
alpha-methyl-2,4-dihydroxyphenylalanine | IC50: 1.8 mM | Locusta migratoria |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Locusta migratoria | |
0.007 | - |
L-tyrosine | pH 7, 32°C | Locusta migratoria | |
0.117 | - |
L-Dopa | pH 7, 32°C | Locusta migratoria |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
370000 | - |
gel filtration | Locusta migratoria |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Tyrosine | Locusta migratoria | - |
Tyramine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Locusta migratoria | - |
migratorioides R.F., locust | - |
Purification (Comment) | Organism |
---|---|
partial | Locusta migratoria |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | cerebral ganglia | Locusta migratoria | - |
additional information | enzyme activity decreases in the different ganglia in the following order: optic lobes, cerebral ganglia, thoracic ganglia, sub-oesophageal ganglion, abdominal ganglia | Locusta migratoria | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Dopa | 16times lower affinity for DOPA than for tyrosine, the decarboxylation of DOPA is inhibited in the presence of the cofactor pyridoxal 5-phosphate by 50-60%, maximum activity towards DOPA in the absence of the cofactor | Locusta migratoria | dopamine + CO2 | - |
? | |
L-Tyrosine | - |
Locusta migratoria | Tyramine + CO2 | - |
? | |
L-Tyrosine | 16times higher affinity for tyrosine than for DOPA | Locusta migratoria | Tyramine + CO2 | - |
? | |
additional information | not: 5-hydroxytryptophan | Locusta migratoria | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TYR decarboxylase | - |
Locusta migratoria |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
32 | - |
assay at | Locusta migratoria |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | 7.2 | - |
Locusta migratoria |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | cofactor, presence inhibits decarboxylation of DOPA by 50-60% | Locusta migratoria |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0004 | - |
potent inhibitor, IC50: 0.0004 mM | Locusta migratoria | 3-hydroxybenzyl-hydrazine | |
1.8 | - |
IC50: 1.8 mM | Locusta migratoria | alpha-methyl-2,4-dihydroxyphenylalanine | |
6.37 | - |
IC50: 6.37 mM | Locusta migratoria | (2S)-2-amino-3-(3-hydroxyphenyl)-2-methylpropanoic acid | |
9.4 | - |
IC50: 9.4 mM | Locusta migratoria | (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid |