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Literature summary for 4.1.1.19 extracted from

  • Wang, S.; Lv, Q.; Yang, Y.; Guo, L.H.; Wan, B.; Ren, X.; Zhang, H.
    Arginine decarboxylase A novel biological target of mercury compounds identified in PC12 cells (2016), Biochem. Pharmacol., 118, 109-120 .
    View publication on PubMed
Search for more literature for 4.1.1.19

Cloned(Commentary)

Cloned (Comment) Organism
gene ADC, real-time RT-PCR enzyme expression analysis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
ethylmercury 54% inhibition at 0.005 mM Rattus norvegicus
Hg2+ 85% inhibition at 0.005 mM Rattus norvegicus
methylmercury 33% inhibition at 0.005 mM Rattus norvegicus
additional information mercury compounds inhibits the enzyme activity but induce the enzyme expression in PC12 cells, molecular mechanism of mercury compounds' neurotoxicity and enzyme inhibition mechanism, molecular dynamics simulation, product-competitive displacement method, method optimization, overview Rattus norvegicus
phenylmercury 72% inhibition at 0.005 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine Rattus norvegicus
-
 agmatine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
neuron
-
 Rattus norvegicus
-
PC-12 cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine
-
 Rattus norvegicus agmatine + CO2
-
 ?
additional information enzyme activity assay using cucurbit[7]uril (CB7) and fluorescent dye acridine orange, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
ADC
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate PLP, molecular dynamics simulation of PLP binding to ADC, overview Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000796
-
 pH 6.0, 37°C Rattus norvegicus methylmercury

Expression

Organism Comment Expression
Rattus norvegicus mercury compounds inhibits the enzyme activity but induce the enzyme expression in PC12 cells. The results indicate that ADC inhibition in PC12 cells by the four Hg compounds is due to the loss of enzyme activity, not protein level additional information
Rattus norvegicus 0.005 mlM MeHg, EtHg, PhHg and HgCl2 increase the protein expression by 1.23, 1.06, 1.45, and 1.33fold, respectively up

General Information

General Information Comment Organism
physiological function arginine decarboxylase (ADC) is a key enzyme in the central agmatinergic system Rattus norvegicus