Literature summary for 4.1.1.18 extracted from

Li, N.; Chou, H.; Xu, Y.
Improved cadaverine production from mutant Klebsiella oxytoca lysine decarboxylase (2016), Eng. Life Sci., 16, 299-305 .

No PubMed abstract available

Cloned(Commentary)

Cloned (Comment)	Organism
gene ldc, recombinant expression of codon-optimized enzyme in Escherichia coli K-12 resulting in strain LN20, optimizing the sequence located in the region of the ribosome-binding site in order to enhance translation efficiency further improves the system, subcloning in Escherichia coli TOP10 cells. Batch and fed-batch production of Klebsiella oxytoca lysine decarboxylase from several modifed strains, overview	Klebsiella oxytoca

Cloned (Comment)

Organism

gene ldc, recombinant expression of codon-optimized enzyme in Escherichia coli K-12 resulting in strain LN20, optimizing the sequence located in the region of the ribosome-binding site in order to enhance translation efficiency further improves the system, subcloning in Escherichia coli TOP10 cells. Batch and fed-batch production of Klebsiella oxytoca lysine decarboxylase from several modifed strains, overview

Klebsiella oxytoca

Protein Variants

Protein Variants	Comment	Organism
additional information	identification of mutant Ldc-co with increased lysine decarboxylase ability. Codon optimization of the gene encoding the enzyme is carried on for the heterologous expression in Escherichia coli. Identification of mutant lysine decarboxylase enzymes with enhanced cadaverine-production ability. Together, these modifications increase cadaverine production in the system by 50%, and the system has a yield of 80% from lysine-HCl, the system to produce cadaverine using the lysine decarboxylase from Klebsiella oxytoca performs at a level that is competitive with the traditional systems using the Escherichia coli lysine decarboxylases in both lab-scale and batch fermentation conditions. Generation of several mutant strains and evaluation, overview	Klebsiella oxytoca

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-lysine	Klebsiella oxytoca	-	cadaverine + CO2	-	?
L-lysine	Klebsiella oxytoca DSM 6673	-	cadaverine + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Klebsiella oxytoca	-	-	-
Klebsiella oxytoca DSM 6673	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-lysine	-	Klebsiella oxytoca	cadaverine + CO2	-	?
L-lysine	-	Klebsiella oxytoca DSM 6673	cadaverine + CO2	-	?

Synonyms

Synonyms	Comment	Organism
LDC	-	Klebsiella oxytoca

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Klebsiella oxytoca