Literature summary for 4.1.1.17 extracted from

Liao, Y.F.; Hung, H.C.; Hsu, P.C.; Kao, M.C.; Hour, T.C.; Tsay, G.J.; Liu, G.Y.
Ornithine decarboxylase interferes with macrophage-like differentiation and matrix metalloproteinase-9 expression by tumor necrosis factor alpha via NF-kappaB (2008), Leuk. Res., 32, 1124-1140.

Search for more literature for 4.1.1.17

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of ODC, expression analysis, overview	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression of ODC leads to restored MMP-9 secretion involving stimulation by TNF-alpha, and reduced MMP-9 activity and expression during macrophage-like differentiation	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha-difluoromethylornithine	an irreversible inhibitor of ODC, cannot recover MMP-9 activation following NF-kappaB inhibitor treatment in parental cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-ornithine	Homo sapiens	-	putrescine + CO2	-	?
additional information	Homo sapiens	ornithine decarboxylase, the rate-limiting enzyme of polyamine biosynthesis, is a tumor promoter, provokes cell proliferation, and inhibits cell death, it interferes with macrophage-like differentiation and matrix metalloproteinase-9 expression by tumor necrosis factor alpha via NF-kappaB, ODC can directly inhibit and attenuate NF-kappaB DNA binding and transcriptional activation, mechanism, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HL-60 cell	-	Homo sapiens	-
promonocytic leukemia cell	-	Homo sapiens	-
promyelocytic leukemia cell	-	Homo sapiens	-
U-937 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-ornithine	-	Homo sapiens	putrescine + CO2	-	?
additional information	ornithine decarboxylase, the rate-limiting enzyme of polyamine biosynthesis, is a tumor promoter, provokes cell proliferation, and inhibits cell death, it interferes with macrophage-like differentiation and matrix metalloproteinase-9 expression by tumor necrosis factor alpha via NF-kappaB, ODC can directly inhibit and attenuate NF-kappaB DNA binding and transcriptional activation, mechanism, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
ODC	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.1	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Homo sapiens

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Release 2023.1 (January 2023)