Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | glutamate reduces the expression of isozymes GAD65 and GAD67, glutamate's suppressing effect on GAD protein isoforms is significantly attenuated by preincubation with the cysteine protease inhibitor N-acetyl-L-leucyl-L-leucyl-L-norleucinal via blockade of calpain and cathepsin protease activities, overview | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | removing extracellular calcium prevents the NMDAR-mediated decrease in GAD protein levels, whereas inhibiting calcium entry through voltage-gated calcium channels has no effect | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamate | Mus musculus | - |
4-aminobutanoate + CO2 | - |
? | |
L-glutamate | Mus musculus BALB/c | - |
4-aminobutanoate + CO2 | - |
? | |
additional information | Mus musculus | cortical GABAergic neurons, surviving pathological insult such as ischemia or brain trauma, exposed to glutamate in vitro, display an NMDA receptor-mediated alteration in the levels of the GABA synthesizing enzyme glutamic acid decarboxylase, isozymes GAD65 and 67, mechanism of glutamate excitotoxicity, overview | ? | - |
? | |
additional information | Mus musculus BALB/c | cortical GABAergic neurons, surviving pathological insult such as ischemia or brain trauma, exposed to glutamate in vitro, display an NMDA receptor-mediated alteration in the levels of the GABA synthesizing enzyme glutamic acid decarboxylase, isozymes GAD65 and 67, mechanism of glutamate excitotoxicity, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
Balb/c mice | - |
Mus musculus BALB/c | - |
Balb/c mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
cerebral cortex | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamate | - |
Mus musculus | 4-aminobutanoate + CO2 | - |
? | |
L-glutamate | - |
Mus musculus BALB/c | 4-aminobutanoate + CO2 | - |
? | |
additional information | cortical GABAergic neurons, surviving pathological insult such as ischemia or brain trauma, exposed to glutamate in vitro, display an NMDA receptor-mediated alteration in the levels of the GABA synthesizing enzyme glutamic acid decarboxylase, isozymes GAD65 and 67, mechanism of glutamate excitotoxicity, overview | Mus musculus | ? | - |
? | |
additional information | cortical GABAergic neurons, surviving pathological insult such as ischemia or brain trauma, exposed to glutamate in vitro, display an NMDA receptor-mediated alteration in the levels of the GABA synthesizing enzyme glutamic acid decarboxylase, isozymes GAD65 and 67, mechanism of glutamate excitotoxicity, overview | Mus musculus BALB/c | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GAD | - |
Mus musculus |
Glutamic acid decarboxylase | - |
Mus musculus |