Literature summary for 4.1.1.102 extracted from

Ferguson, K.L.; Eschweiler, J.D.; Ruotolo, B.T.; Marsh, E.N.G.
Evidence for a 1,3-dipolar cyclo-addition mechanism in the decarboxylation of phenylacrylic acids catalyzed by ferulic acid decarboxylase (2017), J. Am. Chem. Soc., 139, 10972-10975 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
(Z)-2-fluoro-2-nitro-vinylbenzene	potent irreversible inhibitor. At 0.05 mM, enzyme is inactive within 10 min	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	Q03034	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	proposed mechanism involves the formation of a putative pentacyclic intermediate formed by a 1,3 dipolar cyclo-addition of cofactor prenylated FMN with the alpha-beta double bond of the substrate, which serves to activate the substrate toward decarboxylation. Prenylated FMN is able to function as a dipole in a 1,3 dipolar cyclo-addition reaction as the initial step	Saccharomyces cerevisiae	?	-	?

Synonyms

Synonyms	Comment	Organism
FDC1	-	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
FMN	cofactor is prenylated FMN	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)